PRA3006-SPARQL

keyeventWithTitle.rq

Database	AOP-Wiki
SPARQl endpoint	https://aopwiki.rdf.bigcat-bioinformatics.org/sparql
License	Ask Marvin

Code examples: curl

SPARQL

SELECT ?KE ?KEtitle
WHERE {
  ?KE a aopo:KeyEvent .
  ?KE dc:title ?KEtitle .
}

Run or Edit

Output

KE	KEtitle
https://identifiers.org/aop.events/2069	Occurrence, Vascular Remodeling
https://identifiers.org/aop.events/2070	Increase, Glycolysis
https://identifiers.org/aop.events/2071	Decrease, Glucose pool
https://identifiers.org/aop.events/2072	Increase, Mitochondrial swelling
https://identifiers.org/aop.events/2073	increase oxidation of the di-copper moiety of the hemocyanin active site
https://identifiers.org/aop.events/2074	Decreased, oxygen binding capacity by hemocyanin
https://identifiers.org/aop.events/2075	Cognitive, sensed as hypoxic/low oxygen environment
https://identifiers.org/aop.events/2076	Increase, hemocyanin mRNA
https://identifiers.org/aop.events/2077	Increase, pulmonate breathing
https://identifiers.org/aop.events/2078	Loss of drebrin
https://identifiers.org/aop.events/2079	Increased glycolipid levels in testis
https://identifiers.org/aop.events/2080	Impaired, blood testis barrier
https://identifiers.org/aop.events/2081	Increased Modified Proteins
https://identifiers.org/aop.events/2083	Occurrence of Cataracts
https://identifiers.org/aop.events/1000	stabilization, PPAR alpha co-repressor
https://identifiers.org/aop.events/1002	Inhibition, Deiodinase 2
https://identifiers.org/aop.events/1003	Decreased, Triiodothyronine (T3)
https://identifiers.org/aop.events/1009	Inhibition, Deiodinase 1
https://identifiers.org/aop.events/110	Impairment, Endothelial network
https://identifiers.org/aop.events/1108	Abnormal, Role change within caste
https://identifiers.org/aop.events/112	Antagonism, Estrogen receptor
https://identifiers.org/aop.events/115	Increase, FA Influx
https://identifiers.org/aop.events/116	Activation, FAS
https://identifiers.org/aop.events/1172	Increase activation, Nuclear factor kappa B (NF-kB)
https://identifiers.org/aop.events/119	N/A, Gap
https://identifiers.org/aop.events/1193	N/A, Breast Cancer
https://identifiers.org/aop.events/12	Acetylcholinesterase (AchE) Inhibition
https://identifiers.org/aop.events/1202	Suppression, IL-2 and IL-4 production
https://identifiers.org/aop.events/1214	Altered gene expression specific to CAR activation, Hepatocytes
https://identifiers.org/aop.events/1243	Altered, Ca2+-calmodulin activated signal transduction
https://identifiers.org/aop.events/1253	MLL chromosomal translocation
https://identifiers.org/aop.events/1254	Infant leukaemia
https://identifiers.org/aop.events/1269	Increase, COX-2 expression
https://identifiers.org/aop.events/139	N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
https://identifiers.org/aop.events/1391	Activation of Cyp2E1
https://identifiers.org/aop.events/1458	Pulmonary fibrosis
https://identifiers.org/aop.events/1477	Decrease, Oxidative phosphorylation
https://identifiers.org/aop.events/1494	Leukocyte recruitment/activation
https://identifiers.org/aop.events/1498	Loss of alveolar capillary membrane integrity
https://identifiers.org/aop.events/1499	Increased, activation of T (T) helper (h) type 2 cells
https://identifiers.org/aop.events/1500	Increased, fibroblast proliferation and myofibroblast differentiation
https://identifiers.org/aop.events/1501	Increased, extracellular matrix deposition
https://identifiers.org/aop.events/1502	Histone deacetylase inhibition
https://identifiers.org/aop.events/1503	Histone acetylation, increase
https://identifiers.org/aop.events/1506	Testicular atrophy
https://identifiers.org/aop.events/1508	CYP2E1 Activation
https://identifiers.org/aop.events/1510	Oxidative Stress in Brain
https://identifiers.org/aop.events/1512	Unfolded Protein Response
https://identifiers.org/aop.events/1513	General Apoptosis
https://identifiers.org/aop.events/1522	Inhibition, Chitin synthase 1
https://identifiers.org/aop.events/1528	Fatty Acid Beta Oxidation, Decreased
https://identifiers.org/aop.events/1542	Increase, Mitochondrial complex III antagonism
https://identifiers.org/aop.events/1543	Mitochondrial Complex IV inhibition
https://identifiers.org/aop.events/1544	Mitochondrial Complex V inhibition
https://identifiers.org/aop.events/1549	Liver Injury
https://identifiers.org/aop.events/155	Inadequate DNA repair
https://identifiers.org/aop.events/1557	Neural crest cell migration, reduced
https://identifiers.org/aop.events/1564	Chemical induced Fanconi syndrome
https://identifiers.org/aop.events/1574	Inhibition, IKK complex
https://identifiers.org/aop.events/1575	Activation, Caspase 8 pathway
https://identifiers.org/aop.events/1599	Inflamatory events in light-exposed tissues
https://identifiers.org/aop.events/1604	Inhibition of N-linked glycosylation
https://identifiers.org/aop.events/1614	Decrease, androgen receptors (AR) activation
https://identifiers.org/aop.events/1616	Malformation, cryptorchidism - maldescended testis
https://identifiers.org/aop.events/165	Activation, Long term AHR receptor driven direct and indirect gene expression changes
https://identifiers.org/aop.events/1650	Epithelial-mesenchymal transition
https://identifiers.org/aop.events/1651	Treatment-resistant gastric cancer
https://identifiers.org/aop.events/1656	Antagonism, Thyroid Receptor
https://identifiers.org/aop.events/167	Activation, LXR
https://identifiers.org/aop.events/1688	anogenital distance (AGD), decreased
https://identifiers.org/aop.events/1700	Impaired IL-1R1 signaling in T cell
https://identifiers.org/aop.events/1702	Suppression of T cell activation
https://identifiers.org/aop.events/1706	Stimulation, TLR7/8
https://identifiers.org/aop.events/1707	Increase, IL-23 from matured dendritic cells
https://identifiers.org/aop.events/1708	Th17 cell migration and inflammation induction
https://identifiers.org/aop.events/1709	Psoriatic skin disease
https://identifiers.org/aop.events/1710	Binding to estrogen receptor (ER)-α in immune cells
https://identifiers.org/aop.events/1711	Induction of GATA3 expression
https://identifiers.org/aop.events/1712	Increase of Th2 cells producing IL-4
https://identifiers.org/aop.events/1713	Increase of anti-DNA antibody from autoreactive B cell
https://identifiers.org/aop.events/1714	Exacerbation of systemic lupus erythematosus (SLE)
https://identifiers.org/aop.events/1715	Inhibition of JAK3
https://identifiers.org/aop.events/1716	Blockade of STAT5 phosphorylation
https://identifiers.org/aop.events/1717	Suppression of STAT5 binding to cytokine gene promoters
https://identifiers.org/aop.events/1718	Suppression of IL-4 production
https://identifiers.org/aop.events/1719	Impairment of T-cell dependent antibody response
https://identifiers.org/aop.events/1720	Trypsin inhibition
https://identifiers.org/aop.events/1721	Increased intestinal monitor peptide level
https://identifiers.org/aop.events/1722	Increased blood CCK level
https://identifiers.org/aop.events/1723	Increased exocrine secretion from pancreatic acinar cells
https://identifiers.org/aop.events/1724	Acinar cell proliferation
https://identifiers.org/aop.events/1725	Pancreatic acinar cell tumors
https://identifiers.org/aop.events/1739	Binding to ACE2
https://identifiers.org/aop.events/1754	Porcupine-induced Wnt secretion and Wnt signaling activation
https://identifiers.org/aop.events/1759	Increase, Cripto-1 expression
https://identifiers.org/aop.events/1760	Inhibition, Activin signaling
https://identifiers.org/aop.events/18	Activation, AhR
https://identifiers.org/aop.events/1822	Maturation of TNF/iNOS-Producing Dendritic Cells
https://identifiers.org/aop.events/1841	Encephalitis
https://identifiers.org/aop.events/1848	Toll Like Receptor (TLR) Dysregulation
https://identifiers.org/aop.events/186	Altered, Neuroanatomy
https://identifiers.org/aop.events/201	Binding of antagonist, NMDA receptors
https://identifiers.org/aop.events/258	Activation, SCD-1
https://identifiers.org/aop.events/26	Antagonism, Androgen receptor
https://identifiers.org/aop.events/264	Activation, SREBP-1c
https://identifiers.org/aop.events/272	Activation/Proliferation, T-cells
https://identifiers.org/aop.events/277	Thyroid hormone synthesis, Decreased
https://identifiers.org/aop.events/279	Thyroperoxidase, Inhibition
https://identifiers.org/aop.events/28	Reduction, Angiogenesis
https://identifiers.org/aop.events/280	Thyroxine (T4) in neuronal tissue, Decreased
https://identifiers.org/aop.events/281	Thyroxine (T4) in serum, Decreased
https://identifiers.org/aop.events/286	Altered, Transcription of genes by AR
https://identifiers.org/aop.events/298	Insufficiency, Vascular
https://identifiers.org/aop.events/305	Inhibition, VegfR2
https://identifiers.org/aop.events/350	Increase, Mortality
https://identifiers.org/aop.events/352	N/A, Neurodegeneration
https://identifiers.org/aop.events/36	Inhibition, Aromatase
https://identifiers.org/aop.events/369	Uroporphyria
https://identifiers.org/aop.events/381	Reduced levels of BDNF
https://identifiers.org/aop.events/385	Decrease of synaptogenesis
https://identifiers.org/aop.events/389	Increased, Intracellular Calcium overload
https://identifiers.org/aop.events/408	reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
https://identifiers.org/aop.events/41	Inhibition, Bile Salt Export Pump (ABCB11)
https://identifiers.org/aop.events/424	Inhibition, Na+/I- symporter (NIS)
https://identifiers.org/aop.events/425	Decrease of Thyroidal iodide
https://identifiers.org/aop.events/51	Inhibition, Ca++ ATPase
https://identifiers.org/aop.events/54	Up Regulation, CD36
https://identifiers.org/aop.events/584	Inhibition, sodium channel
https://identifiers.org/aop.events/619	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
https://identifiers.org/aop.events/66	Activation, ChREBP
https://identifiers.org/aop.events/663	Desensitization, Nicotinic acetylcholine receptor
https://identifiers.org/aop.events/669	Reduction, Neuronal synaptic inhibition
https://identifiers.org/aop.events/715	Activation, Constitutive androstane receptor
https://identifiers.org/aop.events/716	Increase, cell proliferation (hepatocytes)
https://identifiers.org/aop.events/752	Altered, Meiotic chromosome dynamics
https://identifiers.org/aop.events/79	Inhibition, Cyclooxygenase activity
https://identifiers.org/aop.events/826	Activation, Keratinocytes
https://identifiers.org/aop.events/851	Decrease of GABAergic interneurons
https://identifiers.org/aop.events/853	Changes/Inhibition, Cellular Homeostasis and Apoptosis
https://identifiers.org/aop.events/856	Formation, Hepatocellular and Bile duct tumors
https://identifiers.org/aop.events/858	Decreased, PPARalpha transactivation of gene expression
https://identifiers.org/aop.events/877	Inhibition, organic anion transporter 1 (OAT1)
https://identifiers.org/aop.events/887	Inhibition, NADH-ubiquinone oxidoreductase (complex I)
https://identifiers.org/aop.events/888	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
https://identifiers.org/aop.events/89	Synthesis, De Novo FA
https://identifiers.org/aop.events/927	KE1 : S-Glutathionylation, eNOS
https://identifiers.org/aop.events/935	KE2 : Decrease, GTPCH-1
https://identifiers.org/aop.events/941	Activation, EGFR
https://identifiers.org/aop.events/944	dimerization, AHR/ARNT
https://identifiers.org/aop.events/948	reduced production, VEGF
https://identifiers.org/aop.events/957	Binding, Transthyretin in serum
https://identifiers.org/aop.events/958	Displacement, Serum thyroxine (T4) from transthyretin
https://identifiers.org/aop.events/959	Increased, Free serum thyroxine (T4)
https://identifiers.org/aop.events/960	Increased, Uptake of thyroxine into tissue
https://identifiers.org/aop.events/961	Increased, Clearance of thyroxine from serum
https://identifiers.org/aop.events/962	Increase, Mucin production
https://identifiers.org/aop.events/973	KE5 : Decrease, AKT/eNOS activity
https://identifiers.org/aop.events/979	Interference, nuclear localization of NFAT
https://identifiers.org/aop.events/980	Inhibition, Calcineurin Activity
https://identifiers.org/aop.events/981	Reduction, NFAT/AP-1 complex formation
https://identifiers.org/aop.events/984	Impairment, T-cell dependent antibody response
https://identifiers.org/aop.events/10	Acetylcholine accumulation in synapses
https://identifiers.org/aop.events/1001	Increased, Developmental Defects
https://identifiers.org/aop.events/1004	Reduced, Posterior swim bladder inflation
https://identifiers.org/aop.events/1005	Reduced, Swimming performance
https://identifiers.org/aop.events/1007	Reduced, Anterior swim bladder inflation
https://identifiers.org/aop.events/1012	Increased, Inhibitory postsynaptic potential
https://identifiers.org/aop.events/1014	Induction, Somatic muscle paralysis
https://identifiers.org/aop.events/1015	Increased, Neuronal synaptic inhibition
https://identifiers.org/aop.events/1016	Inhibition, Feeding
https://identifiers.org/aop.events/1018	Activation, Glutamate-gated chloride channels
https://identifiers.org/aop.events/1019	Induction, pharyngeal muscle paralysis
https://identifiers.org/aop.events/1023	Increased, Thyroid-stimulating hormone (TSH)
https://identifiers.org/aop.events/1028	Activation of specific nuclear receptors, PPAR-gamma activation
https://identifiers.org/aop.events/1029	Increased, adipogenesis
https://identifiers.org/aop.events/103	Increase, Ecdysone receptor agonism
https://identifiers.org/aop.events/1032	Increased, secretion of local growth factors
https://identifiers.org/aop.events/1033	Increased, proliferation of mesenchymal cells
https://identifiers.org/aop.events/1034	Increased, IGF-1 (mouse)
https://identifiers.org/aop.events/1035	Increased, Firbrosarcoma
https://identifiers.org/aop.events/1036	Increased, liposarcoma
https://identifiers.org/aop.events/1037	Increased, hemagiosarcoma
https://identifiers.org/aop.events/1038	Activation, beta-2 adrenergic receptor
https://identifiers.org/aop.events/1039	Increased activity, beta-2 adrenergic receptor
https://identifiers.org/aop.events/1040	relaxation, smooth muscle
https://identifiers.org/aop.events/1042	Proliferation/Clonal Expansion, smooth muscle
https://identifiers.org/aop.events/1043	Hypertrophy/hyperplasia, smooth muscle
https://identifiers.org/aop.events/1044	Promotion, mesovarian leiomyomas
https://identifiers.org/aop.events/1045	Decreased, Ovarian E2
https://identifiers.org/aop.events/1046	Suppression, Estrogen receptor (ER) activity
https://identifiers.org/aop.events/1047	Increased, secretion of GnRH from hypothalamus
https://identifiers.org/aop.events/1049	Increased, secrection of FSH from anterior pituitary
https://identifiers.org/aop.events/1050	Increased, secretion of LH from anterior pituitary
https://identifiers.org/aop.events/1051	Hyperplasia, ovarian stromal cells
https://identifiers.org/aop.events/1052	Hyperplasia, ovarian epithelium
https://identifiers.org/aop.events/1053	Promotion, ovarian adenomas
https://identifiers.org/aop.events/1054	Promotion, ovarian granular cell tumors
https://identifiers.org/aop.events/1056	Decrease, E2 blood concentrations at hypothalamus
https://identifiers.org/aop.events/1057	Increased, PPAR-alpha activation
https://identifiers.org/aop.events/1058	Decreased, bile flow
https://identifiers.org/aop.events/1059	Increased, cholestasis
https://identifiers.org/aop.events/106	Reduction, Eggshell thickness
https://identifiers.org/aop.events/1060	Alteration, lipid metabolism
https://identifiers.org/aop.events/1061	prolonged, elevation of serun CCK
https://identifiers.org/aop.events/1062	Increased, Cellular proliferation / hyperplasia of acinar cells
https://identifiers.org/aop.events/1063	Increased, Pancreatic acinar tumors
https://identifiers.org/aop.events/1064	prepubertal increase, Estrogen receptor (ER) activity
https://identifiers.org/aop.events/1065	Activation, estrogen receptor alpha
https://identifiers.org/aop.events/1066	Promotion, SIX-1 postive basal-type progenitor cells
https://identifiers.org/aop.events/1067	Proliferation/Clonal Expansion, aberrant basal cells
https://identifiers.org/aop.events/1068	squamous metaplasia, aberrant basal cells
https://identifiers.org/aop.events/1069	Increased, Hyperplasia (glandular epithelial cells of endometrium)
https://identifiers.org/aop.events/1070	Increased, adenosquamous carcinomas of endometrium
https://identifiers.org/aop.events/1071	Decreased, GnRH pulsatility/release in hypothalamus
https://identifiers.org/aop.events/1072	Decreased, LH Surge from anterior pituitary
https://identifiers.org/aop.events/1074	interruption, Ovulation
https://identifiers.org/aop.events/1075	prolonged, estrus
https://identifiers.org/aop.events/1076	Increased, circulating estrogen levels
https://identifiers.org/aop.events/1077	Increased, prolactin exposure
https://identifiers.org/aop.events/1078	Hyperplasia, Mammary gland
https://identifiers.org/aop.events/1079	Increased, Adenomas/carcinomas (mammary)
https://identifiers.org/aop.events/1080	Increased, latency period
https://identifiers.org/aop.events/1081	Increased, lactotroph hyperplasia and hypertrophy
https://identifiers.org/aop.events/1082	Increased, adenomas (pituitary)
https://identifiers.org/aop.events/1083	Decreased, Dopaminergic activity
https://identifiers.org/aop.events/1084	Increased, prolactin secretion
https://identifiers.org/aop.events/1085	Increased, hyperplasia (mammary gland)
https://identifiers.org/aop.events/1086	persistent, cytotoxicity (pleura or peritoneum)
https://identifiers.org/aop.events/1087	Increased, inflammation
https://identifiers.org/aop.events/1088	Increased, Oxidative Stress
https://identifiers.org/aop.events/1089	Increased, Cell Proliferation (mesothelium)
https://identifiers.org/aop.events/1090	Increased, mesotheliomas
https://identifiers.org/aop.events/1096	Increased, blood uric acid concentration
https://identifiers.org/aop.events/1097	Occurrence, renal proximal tubular necrosis
https://identifiers.org/aop.events/1098	Increased, blood potassium concentration
https://identifiers.org/aop.events/1101	Altered, Amphibian metamorphosis
https://identifiers.org/aop.events/1102	Occurrence, tophi (urate) deposition
https://identifiers.org/aop.events/1103	Inhibition, Cyclooxygenase 1 activity
https://identifiers.org/aop.events/1104	Decreased, Prostaglandin F2alpha concentration, plasma
https://identifiers.org/aop.events/1105	Occurrence, renal ischemia
https://identifiers.org/aop.events/1106	Occurrence, cardiac arrhythmia
https://identifiers.org/aop.events/1107	Weakened, Colony
https://identifiers.org/aop.events/1109	Increased, Deformed Wing Virus levels
https://identifiers.org/aop.events/111	Agonism, Estrogen receptor
https://identifiers.org/aop.events/1110	Increased, Energetic demands and therefore metabolic stress
https://identifiers.org/aop.events/1114	Unknown, MIE
https://identifiers.org/aop.events/1115	Increased, Reactive oxygen species
https://identifiers.org/aop.events/1116	Decreased, Triiodothyronine (T3) in tissues
https://identifiers.org/aop.events/1122	Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
https://identifiers.org/aop.events/1130	Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
https://identifiers.org/aop.events/1131	Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
https://identifiers.org/aop.events/1132	Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
https://identifiers.org/aop.events/1133	Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
https://identifiers.org/aop.events/1134	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
https://identifiers.org/aop.events/1135	Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
https://identifiers.org/aop.events/1136	Impaired recruitment , Population trajectory
https://identifiers.org/aop.events/1138	Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
https://identifiers.org/aop.events/1139	Increased, water retention in foot
https://identifiers.org/aop.events/1141	Decreased, Reproductive Success
https://identifiers.org/aop.events/1142	Increased, valve movement
https://identifiers.org/aop.events/1143	Depletion, energy reserves
https://identifiers.org/aop.events/1151	Osteoporosis and vascular calcification, Bone deterioration
https://identifiers.org/aop.events/1152	Inhibition, Iodotyrosine deiodinase (IYD)
https://identifiers.org/aop.events/1153	Inhibition, Deiodinase 3
https://identifiers.org/aop.events/1154	Increased, Triiodothyronine (T3) in tissues
https://identifiers.org/aop.events/1155	Inhibition, Pendrin
https://identifiers.org/aop.events/1156	Inhibition, Dual oxidase
https://identifiers.org/aop.events/1157	Activation, Hepatic nuclear receptor(s)
https://identifiers.org/aop.events/1158	Increased, Hepatic thyroid hormone uptake/transport
https://identifiers.org/aop.events/1161	Increased, oocyte maturation
https://identifiers.org/aop.events/1163	Increased, Reproductive Success
https://identifiers.org/aop.events/1164	Increased, Population
https://identifiers.org/aop.events/1169	Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
https://identifiers.org/aop.events/1170	Increase, Phenotypic enzyme activity
https://identifiers.org/aop.events/1171	Increase, Clonal Expansion of Altered Hepatic Foci
https://identifiers.org/aop.events/1174	Activation, NADPH Oxidase
https://identifiers.org/aop.events/1176	Decreased, sodium conductance 2
https://identifiers.org/aop.events/1179	Decreased, GABA release
https://identifiers.org/aop.events/118	Formation, Formation of hemoglobin adducts
https://identifiers.org/aop.events/1181	Activation, Estrogen receptor
https://identifiers.org/aop.events/1182	Increase, Cell Proliferation (Epithelial Cells)
https://identifiers.org/aop.events/1183	Decreased, Apoptosis (Epithelial Cells)
https://identifiers.org/aop.events/1187	Increased, ER binding to DNA (classical pathway)
https://identifiers.org/aop.events/1188	Increased, ER binding to T.F. to DNA (non-classical pathway)
https://identifiers.org/aop.events/1189	Increased, Proliferation (Endothelial cells)
https://identifiers.org/aop.events/1190	Increased, Migration (Endothelial Cells)
https://identifiers.org/aop.events/1191	Increased, Non-genomic signaling
https://identifiers.org/aop.events/1192	Increased, Ductal Hyperplasia
https://identifiers.org/aop.events/1194	Increase, DNA damage
https://identifiers.org/aop.events/1195	modulation, Extracellular Matrix Composition
https://identifiers.org/aop.events/1196	Increased, Invasion
https://identifiers.org/aop.events/1197	Activation, Fibroblasts
https://identifiers.org/aop.events/1198	Activation, Macrophages
https://identifiers.org/aop.events/1205	Activation, Juvenile hormone receptor
https://identifiers.org/aop.events/1206	Induction, Doublesex1 gene
https://identifiers.org/aop.events/1208	Increased, Male offspring
https://identifiers.org/aop.events/1209	Induction, Male reproductive tract
https://identifiers.org/aop.events/1210	Alteration, Food-web structures
https://identifiers.org/aop.events/1213	Increased, Angiogenesis
https://identifiers.org/aop.events/1215	TRPA1 activation, TRPA1 Receptor
https://identifiers.org/aop.events/1218	Opening of calcium channel, Calcium influx
https://identifiers.org/aop.events/122	Activation, Glucocorticoid Receptor
https://identifiers.org/aop.events/1220	Trigeminal nerve activation
https://identifiers.org/aop.events/1222	SP (Substance P) release, Local increase of SP
https://identifiers.org/aop.events/1223	Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
https://identifiers.org/aop.events/1226	Increased Respiratory irritability and Chronic Cough,
https://identifiers.org/aop.events/1239	Altered, Gene Expression
https://identifiers.org/aop.events/1240	Altered, Protein Production
https://identifiers.org/aop.events/1241	Increased, Motility
https://identifiers.org/aop.events/1242	Increased, Second Messenger Production
https://identifiers.org/aop.events/1250	Decrease, Lung function
https://identifiers.org/aop.events/1252	Binding to (interferes with) topoisomerase II enzyme
https://identifiers.org/aop.events/1255	induced spawning
https://identifiers.org/aop.events/1256	increased mantel display
https://identifiers.org/aop.events/1257	Induced parturition
https://identifiers.org/aop.events/1258	Decompartmentalization
https://identifiers.org/aop.events/1259	narcosis
https://identifiers.org/aop.events/1260	Direct mitochondrial inhibition
https://identifiers.org/aop.events/1261	Mitochondrial impairment
https://identifiers.org/aop.events/1262	Apoptosis
https://identifiers.org/aop.events/1263	Necrosis
https://identifiers.org/aop.events/1264	Increase, Nuclear receptor E75b gene expression
https://identifiers.org/aop.events/1265	Increase, Fushi tarazu factor-1 gene expression
https://identifiers.org/aop.events/1266	Decrease, Circulating crustacean cardioactive peptide
https://identifiers.org/aop.events/1267	Decrease, Ecdysis motoneuron bursts
https://identifiers.org/aop.events/1268	Decrease, Excitatory postsynaptic potential
https://identifiers.org/aop.events/1270	Inactivation of PPARγ
https://identifiers.org/aop.events/1271	Activation of TGF-β signaling
https://identifiers.org/aop.events/1275	Collagen Deposition
https://identifiers.org/aop.events/1276	Lung fibrosis
https://identifiers.org/aop.events/1277	Reproductive failure
https://identifiers.org/aop.events/1278	ROS formation
https://identifiers.org/aop.events/1279	Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
https://identifiers.org/aop.events/1280	Activation, HIF-1
https://identifiers.org/aop.events/1281	Increased, DNA Damage-Repair
https://identifiers.org/aop.events/1282	Activation, JAK/STAT pathway
https://identifiers.org/aop.events/1283	Activation, TGF-beta pathway
https://identifiers.org/aop.events/1284	Up Regulation, SREBF2
https://identifiers.org/aop.events/1285	Up Regulation, Unsaturated fatty acid
https://identifiers.org/aop.events/1286	Down Regulation, GSS and GSTs gene
https://identifiers.org/aop.events/1287	Glutathione synthesis
https://identifiers.org/aop.events/1288	Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
https://identifiers.org/aop.events/1289	Perturbation of cholesterol
https://identifiers.org/aop.events/129	Reduction, Gonadotropins, circulating concentrations
https://identifiers.org/aop.events/1290	Glutathione homeostasis
https://identifiers.org/aop.events/1291	Hepatotoxicity
https://identifiers.org/aop.events/1292	Activation, JNK
https://identifiers.org/aop.events/1293	Activation, FOXO
https://identifiers.org/aop.events/1294	Inhibition, Wnt pathway
https://identifiers.org/aop.events/1295	Defect of Embryogenesis
https://identifiers.org/aop.events/1305	Increase, cytosolic fatty acid
https://identifiers.org/aop.events/131	Down Regulation, Gulcose-6-phosphate dehydrogenase
https://identifiers.org/aop.events/1316	Inhibit, serotonin transporter activity
https://identifiers.org/aop.events/1317	Decreased, serotonin transporter activity
https://identifiers.org/aop.events/1318	Decreased, extracellular sodium (Na+)
https://identifiers.org/aop.events/1319	Decreased, extracellular chloride (Cl-)
https://identifiers.org/aop.events/1320	Increased, extracellular serotonin
https://identifiers.org/aop.events/1321	Increased, intracellular sodium (Na+)
https://identifiers.org/aop.events/1322	Increased, intracellular chloride (Cl-)
https://identifiers.org/aop.events/1323	Decreased, intracellular serotonin
https://identifiers.org/aop.events/1324	Decreased, packaged serotonin
https://identifiers.org/aop.events/1325	Decreased, synaptic release
https://identifiers.org/aop.events/1326	Increased, 5-HT3 (5-hydroxytryptamine)
https://identifiers.org/aop.events/1328	Inactivated, 5-HTR (serotonin receptors)
https://identifiers.org/aop.events/1329	Reduce expression, BDNF (Brain-derived neurotrophic factor)
https://identifiers.org/aop.events/1330	Decreased, neuroplasticity
https://identifiers.org/aop.events/1334	Increase, cortisone
https://identifiers.org/aop.events/1335	Reduced, BDNF (Brain-derived neurotrophic factor)
https://identifiers.org/aop.events/1336	Activation, 5-HT2A (Serotonin 2A)
https://identifiers.org/aop.events/1337	Activate, PLC (Phospholipase C)
https://identifiers.org/aop.events/1338	Increase, inositol triphosphate
https://identifiers.org/aop.events/1339	Increase, intracellular calcium
https://identifiers.org/aop.events/1340	Activate, calmodulin
https://identifiers.org/aop.events/1341	Increase, myosin light chain phosphorylation
https://identifiers.org/aop.events/1342	Increase, vascular smooth muscle contraction
https://identifiers.org/aop.events/1343	Increase, hypertension
https://identifiers.org/aop.events/1344	Increased, seizure
https://identifiers.org/aop.events/1345	Increased, agitation
https://identifiers.org/aop.events/1346	Increased, depression
https://identifiers.org/aop.events/1347	Decreased, extracellular serotonin
https://identifiers.org/aop.events/1348	Increase, seizure
https://identifiers.org/aop.events/1349	Activated, presynaptic neuron 1
https://identifiers.org/aop.events/1350	Increased, glutamate
https://identifiers.org/aop.events/1351	Activated, NMDA receptor
https://identifiers.org/aop.events/1352	Activated, voltage-gated sodium channel
https://identifiers.org/aop.events/1353	Inhibit, voltage-gated sodium channel
https://identifiers.org/aop.events/1354	Treat, carbamazepine
https://identifiers.org/aop.events/1355	Activated, membrane depolarization
https://identifiers.org/aop.events/1356	Inactive, membrane depolarization
https://identifiers.org/aop.events/1357	Increased, RDX dose
https://identifiers.org/aop.events/1358	Repress, GABA-A receptor
https://identifiers.org/aop.events/1359	Activate, GABA-A receptor
https://identifiers.org/aop.events/1360	Activate, presynaptic neuron 2
https://identifiers.org/aop.events/1361	Increase, GABA
https://identifiers.org/aop.events/1362	Increased, hippocampal hyperdepolarization
https://identifiers.org/aop.events/1363	Increased, epilepsy
https://identifiers.org/aop.events/1364	Increase, Reactive oxygen species
https://identifiers.org/aop.events/1365	Increase, Apoptosis
https://identifiers.org/aop.events/1366	Decrease, Oogenesis
https://identifiers.org/aop.events/1367	Inhibit, gastric ulcer formation
https://identifiers.org/aop.events/1368	Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1)
https://identifiers.org/aop.events/1369	Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1)
https://identifiers.org/aop.events/1370	Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
https://identifiers.org/aop.events/1371	Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
https://identifiers.org/aop.events/1372	Increase, bicarbonate
https://identifiers.org/aop.events/1373	Increase, mucous
https://identifiers.org/aop.events/1374	Increase, mucosal blood flow
https://identifiers.org/aop.events/1375	Increase, platelet aggregation
https://identifiers.org/aop.events/1376	Increase, angiogenesis
https://identifiers.org/aop.events/1377	Decrease, leukocyte adherence
https://identifiers.org/aop.events/1378	Increase, leukocyte adherence
https://identifiers.org/aop.events/1379	Activate, leukocyte
https://identifiers.org/aop.events/1380	Activate, mucosal defense
https://identifiers.org/aop.events/1381	Increase, surfactant
https://identifiers.org/aop.events/1382	Decrease, surfactant
https://identifiers.org/aop.events/1383	Activate, phospholipase
https://identifiers.org/aop.events/1384	Increase, ammonium (NH4+)
https://identifiers.org/aop.events/1385	Activated, gastric ulcer formation
https://identifiers.org/aop.events/1386	CYP7B activity, inhibition
https://identifiers.org/aop.events/1387	7α-hydroxypregnenolone synthesis in the brain, decreased
https://identifiers.org/aop.events/1388	Dopamine release in the brain, decreased
https://identifiers.org/aop.events/1389	Locomotor activity, decreased
https://identifiers.org/aop.events/1390	Sexual behavior, decreased
https://identifiers.org/aop.events/1392	Oxidative Stress
https://identifiers.org/aop.events/1393	Hepatocytotoxicity
https://identifiers.org/aop.events/1394	Induction, persistent proliferation/sustained proliferation
https://identifiers.org/aop.events/1395	Liver Cancer
https://identifiers.org/aop.events/1396	Increased, glucocorticoid receptor activity
https://identifiers.org/aop.events/1397	Increased, serotonin transporter activity
https://identifiers.org/aop.events/1398	Increased, intracellular serotonin
https://identifiers.org/aop.events/1399	Increased, packaged serotonin
https://identifiers.org/aop.events/140	Decreased, HSD17B10 expression
https://identifiers.org/aop.events/1400	Increased, synaptic release
https://identifiers.org/aop.events/1401	Decreased, 5-HT3
https://identifiers.org/aop.events/1402	Reduced, PTGS1 function
https://identifiers.org/aop.events/1403	Reduced, platelet aggregation
https://identifiers.org/aop.events/1404	Decreased, mucosal blood flow
https://identifiers.org/aop.events/1405	Reduced, mucosal defense
https://identifiers.org/aop.events/1406	Decreased, mucous
https://identifiers.org/aop.events/1407	Decreased, bicarbonate
https://identifiers.org/aop.events/1408	Reduced, PTGS2 function
https://identifiers.org/aop.events/1409	Decreased, angiogenesis
https://identifiers.org/aop.events/1410	Increased, leukocyte adherence
https://identifiers.org/aop.events/1411	Increased, leukocyte activation
https://identifiers.org/aop.events/1412	Helicobacter pylori infection
https://identifiers.org/aop.events/1413	Reduced, presynaptic neuron 2 activity
https://identifiers.org/aop.events/1414	Decreased, GABA
https://identifiers.org/aop.events/1415	Reduced, GABA-A receptor activation
https://identifiers.org/aop.events/1416	Decreased, intracellular chloride
https://identifiers.org/aop.events/1417	NFE2/Nrf2 repression
https://identifiers.org/aop.events/1418	Increased, steatosis
https://identifiers.org/aop.events/1419	Reduced, FXR activity
https://identifiers.org/aop.events/142	Hyperplasia, Hyperplasia
https://identifiers.org/aop.events/1420	Reduced, SHP activity
https://identifiers.org/aop.events/1421	Activated, LXR
https://identifiers.org/aop.events/1422	Reduced, PPARalpha
https://identifiers.org/aop.events/1423	Reduced, HSD17B4 activity
https://identifiers.org/aop.events/1424	Reduced, fatty acid beta oxidation
https://identifiers.org/aop.events/1425	Mu Opioid Receptor Agonism
https://identifiers.org/aop.events/1426	Release of G Proteins
https://identifiers.org/aop.events/1427	Opening of G protein gated inward rectifying K channels
https://identifiers.org/aop.events/1428	Analgesia
https://identifiers.org/aop.events/1429	Inhibition of N-type Ca ion channels
https://identifiers.org/aop.events/1430	Inhibition of neurotransmitter vesicle release
https://identifiers.org/aop.events/1431	Serotonin 1A Receptor Agonism
https://identifiers.org/aop.events/1432	Anti-depressant Activity
https://identifiers.org/aop.events/1433	Increased CGRP, neuronal release of CGRP
https://identifiers.org/aop.events/1434	Irritation of nasal mucosa inducing sneeze reflex
https://identifiers.org/aop.events/1435	Increased neurokinin A (NKA) by neuronal cells
https://identifiers.org/aop.events/1438	Acute phase proteins expression, Increased
https://identifiers.org/aop.events/1439	Systemic acute phase response
https://identifiers.org/aop.events/1443	Atherosclerosis
https://identifiers.org/aop.events/1444	Increase, Follicular atresia
https://identifiers.org/aop.events/1445	Increase, Lipid peroxidation
https://identifiers.org/aop.events/1446	Decrease, Coupling of oxidative phosphorylation
https://identifiers.org/aop.events/1447	obesity
https://identifiers.org/aop.events/1448	activation of CCAAT/enhancer-binding protein alpha
https://identifiers.org/aop.events/1449	increased adipogenesis
https://identifiers.org/aop.events/145	Induction, IKB inhibitory protein
https://identifiers.org/aop.events/1450	decreased dopamine
https://identifiers.org/aop.events/1451	decreased reward
https://identifiers.org/aop.events/1452	decreased DNA methylation of tyrosine hydroxylase
https://identifiers.org/aop.events/1453	decreased methylation of dopamine transporter promoter
https://identifiers.org/aop.events/1454	chronic high fat diet
https://identifiers.org/aop.events/1456	Increase, Differentiation of fibroblasts
https://identifiers.org/aop.events/1457	Induction, Epithelial Mesenchymal Transition
https://identifiers.org/aop.events/1461	DNA double-strand break
https://identifiers.org/aop.events/1462	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
https://identifiers.org/aop.events/1463	Inhibition of lysyl oxidase
https://identifiers.org/aop.events/1464	Reduction of collagen crosslinking
https://identifiers.org/aop.events/1465	Weak collagen matrix
https://identifiers.org/aop.events/1466	Notochord distortion or malformations
https://identifiers.org/aop.events/1467	Growth, reduction
https://identifiers.org/aop.events/1468	Activation, Latent Transforming Growth Factor Beta 1
https://identifiers.org/aop.events/1469	Activation, Transforming Growth Factor beta pathway
https://identifiers.org/aop.events/147	Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
https://identifiers.org/aop.events/1471	Increase, Uncoupling of photophosphorylation
https://identifiers.org/aop.events/1472	Decrease, ATP production
https://identifiers.org/aop.events/1473	Decrease, Chlorophyll synthesis
https://identifiers.org/aop.events/1474	Decrease, Light harvest capacity
https://identifiers.org/aop.events/1475	Decrease, Photosynthesis
https://identifiers.org/aop.events/1476	Decrease, Glycolysis
https://identifiers.org/aop.events/1478	Decrease, Leaf cell mitosis
https://identifiers.org/aop.events/1479	Decrease, Leaf development
https://identifiers.org/aop.events/1481	Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
https://identifiers.org/aop.events/1482	Depletion, mtDNA
https://identifiers.org/aop.events/1483	Dysfunction, Mitochondria
https://identifiers.org/aop.events/1486	Binding of substrate, endocytic receptor
https://identifiers.org/aop.events/1487	Binding, Thiol/seleno-proteins involved in protection against oxidative stress
https://identifiers.org/aop.events/1488	Glutamate dyshomeostasis
https://identifiers.org/aop.events/1489	N/A, Steatohepatisis
https://identifiers.org/aop.events/149	Increase, Inflammation
https://identifiers.org/aop.events/1490	Inhibition, Fatty Acid Beta Oxidation
https://identifiers.org/aop.events/1491	Increased, Oncotic Necrosis
https://identifiers.org/aop.events/1492	Tissue resident cell activation
https://identifiers.org/aop.events/1493	Increased Pro-inflammatory mediators
https://identifiers.org/aop.events/1495	Substance interaction with the lung resident cell membrane components
https://identifiers.org/aop.events/1496	Increased, secretion of proinflammatory mediators
https://identifiers.org/aop.events/1497	Increased, recruitment of inflammatory cells
https://identifiers.org/aop.events/1505	Cell cycle, disrupted
https://identifiers.org/aop.events/1509	Protein Adduct Formation
https://identifiers.org/aop.events/1511	Lipid Peroxidation
https://identifiers.org/aop.events/1514	Neurodegeneration
https://identifiers.org/aop.events/1515	Spermatocyte depletion
https://identifiers.org/aop.events/152	Suppression, Inflammatory cytokines
https://identifiers.org/aop.events/1521	Decrease, Growth
https://identifiers.org/aop.events/1523	Decrease, Cuticular chitin content
https://identifiers.org/aop.events/1524	Increase, Premature molting
https://identifiers.org/aop.events/1525	Increase, Sulfonylurea receptor binding
https://identifiers.org/aop.events/1526	Increase, Opening of voltage-dependent calcium channel
https://identifiers.org/aop.events/1527	Increase, Cell membrane depolarization
https://identifiers.org/aop.events/1529	Blockade, L-Type Calcium Channels
https://identifiers.org/aop.events/1530	Decrease, Calcium currents
https://identifiers.org/aop.events/1531	Decrease, Calcium binding to Troponin C
https://identifiers.org/aop.events/1532	Decrease, Cardiac contractility
https://identifiers.org/aop.events/1533	Decrease, Cardiac ejection fraction
https://identifiers.org/aop.events/1535	Heart failure
https://identifiers.org/aop.events/1536	Disruption, Intracellular calcium mobilization
https://identifiers.org/aop.events/1537	Disruption, Sarcomere assembly
https://identifiers.org/aop.events/1538	Decreased protection against oxidative stress
https://identifiers.org/aop.events/1539	Endocytotic lysosomal uptake
https://identifiers.org/aop.events/1545	Decrease in mitochondrial oxidative phosphorylation
https://identifiers.org/aop.events/1546	Increased reactive oxygen species (in the mitochondria)
https://identifiers.org/aop.events/1547	Mitochondrial Injury
https://identifiers.org/aop.events/1548	Necrotic Tissue
https://identifiers.org/aop.events/1556	Increase, lung cancer
https://identifiers.org/aop.events/1558	Collagen production, reduced
https://identifiers.org/aop.events/1559	Facial cartilage structures are reduced in size and morphologically distorted
https://identifiers.org/aop.events/1560	Altered differentiation
https://identifiers.org/aop.events/1561	Neural tube defects
https://identifiers.org/aop.events/1562	Decreased Na/K ATPase activity
https://identifiers.org/aop.events/1563	Decreased proximal tubular vectorial transport
https://identifiers.org/aop.events/1576	Activation, Tissue resident cells (Kuppfer cells)
https://identifiers.org/aop.events/1579	Increase, proinflammatory mediators (TNFalpha)
https://identifiers.org/aop.events/1580	Binding of microtubule stabilizing agents (MSA) to microtubules
https://identifiers.org/aop.events/1581	Disturbance in microtubule dynamic instability
https://identifiers.org/aop.events/1582	Impaired axonial transport
https://identifiers.org/aop.events/1583	Sensory axonal peripheral neuropathy
https://identifiers.org/aop.events/1584	Interaction of α-diketones with arginine residues
https://identifiers.org/aop.events/1585	Proteasomal dysfunction
https://identifiers.org/aop.events/1586	Airway epithelial injury
https://identifiers.org/aop.events/1587	Fibroproliferative airway lesions
https://identifiers.org/aop.events/1588	Bronchiolitis obliterans
https://identifiers.org/aop.events/1592	ROS generation from photoactivated chemicals
https://identifiers.org/aop.events/1594	Oxidation of membrane lipids
https://identifiers.org/aop.events/1595	Oxidation/denatuation of membrane proteins
https://identifiers.org/aop.events/1602	Activation, Muscarinic Acetylcholine Receptors
https://identifiers.org/aop.events/1603	Chronic kidney disease
https://identifiers.org/aop.events/1605	Accumulation of misfolded proteins
https://identifiers.org/aop.events/1606	Activation of hepatic stellate cells
https://identifiers.org/aop.events/1608	Increase, Oxidative DNA damage
https://identifiers.org/aop.events/1609	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
https://identifiers.org/aop.events/161	Increase, Liver and splenic hemosiderosis
https://identifiers.org/aop.events/1610	Reduction, 17-OH-pregnenolone conversion in DHEA
https://identifiers.org/aop.events/1611	Reduction, 17-OH-progesterone conversion in androstenedione
https://identifiers.org/aop.events/1612	Decrease, testosterone synthesis/level
https://identifiers.org/aop.events/1613	Decrease, dihydrotestosterone (DHT) level
https://identifiers.org/aop.events/1615	Impaired inguinoscrotal testicular descent phase
https://identifiers.org/aop.events/1617	5α-reductase, inhibition
https://identifiers.org/aop.events/1619	Increase, DNA methyltransferase inhibition
https://identifiers.org/aop.events/1623	Occurrence, Focal Seizure
https://identifiers.org/aop.events/1627	Inhibition of tyrosinase
https://identifiers.org/aop.events/1628	Reduction of L-Dopaquinone
https://identifiers.org/aop.events/1629	Reduction in melanin level
https://identifiers.org/aop.events/1630	Reduction of melanosome level
https://identifiers.org/aop.events/1631	Reduction fo Pigmentation pattern
https://identifiers.org/aop.events/1632	Increase in reactive oxygen and nitrogen species (RONS)
https://identifiers.org/aop.events/1633	Increase in inflammation
https://identifiers.org/aop.events/1634	Increase, Oxidative damage to DNA
https://identifiers.org/aop.events/1635	Increase, DNA strand breaks
https://identifiers.org/aop.events/1636	Increase, Chromosomal aberrations
https://identifiers.org/aop.events/1637	Retinaldehyde dehydrogenase inhibition
https://identifiers.org/aop.events/164	Induction, Liver “Dysfunctional” Changes by CGA 330050
https://identifiers.org/aop.events/1640	Altered, Photoreceptor patterning
https://identifiers.org/aop.events/1641	Decreased retinoic acid (RA) synthesis
https://identifiers.org/aop.events/1642	Decreased plasma RA level
https://identifiers.org/aop.events/1643	Altered, Visual function
https://identifiers.org/aop.events/1653	Binding of inhibitor to mitochondrial complex III
https://identifiers.org/aop.events/1654	Binding of inhibitor to mitochondrial complex IV
https://identifiers.org/aop.events/1655	Binding of inhibitor to mitochondrial complex V
https://identifiers.org/aop.events/1657	Inhibition of cystathionine beta-synthase
https://identifiers.org/aop.events/166	Decreased, Long-term potentiation (LTP)
https://identifiers.org/aop.events/1661	Increased Homocysteine level
https://identifiers.org/aop.events/1665	Increased, Plasma HCY level
https://identifiers.org/aop.events/1666	Induced, dysfunction of microcirculation
https://identifiers.org/aop.events/1667	Impaired,anterior-posterior axis development
https://identifiers.org/aop.events/1668	Frustrated phagocytosis
https://identifiers.org/aop.events/1669	Increased, DNA damage and mutation
https://identifiers.org/aop.events/1670	Lung cancer
https://identifiers.org/aop.events/1672	Inhibition of lung surfactant function
https://identifiers.org/aop.events/1673	Alveolar collapse
https://identifiers.org/aop.events/1677	Reduced tidal volume
https://identifiers.org/aop.events/168	Decreased, Lymphocytes
https://identifiers.org/aop.events/1680	Inhibition, TBX1
https://identifiers.org/aop.events/1681	Disruption, Neural crest cell migration
https://identifiers.org/aop.events/1682	Disruption, Progenitor cells of second heart field
https://identifiers.org/aop.events/1683	Impairment, Fourth pharyngeal arch development
https://identifiers.org/aop.events/1684	Abnormalities, Cardiac outflow tract formation
https://identifiers.org/aop.events/1685	Anomalies, Congenital cardiac conotruncal
https://identifiers.org/aop.events/1686	Deposition of Energy
https://identifiers.org/aop.events/1687	decrease, transcription of genes by AR
https://identifiers.org/aop.events/169	Disruption, Membrane integrity
https://identifiers.org/aop.events/1690	reduction, testosterone levels
https://identifiers.org/aop.events/1691	Antagonism,LH receptor
https://identifiers.org/aop.events/1692	Reduction, Progesterone synthesis
https://identifiers.org/aop.events/1693	Reduction, Plasma progesterone concentration
https://identifiers.org/aop.events/1694	Reduction, progesterone uptake, decresed maturation
https://identifiers.org/aop.events/1695	Impaired ovulation
https://identifiers.org/aop.events/1696	Decrease of egg production and cummulative fecundity
https://identifiers.org/aop.events/1697	Increase, DNA methyltransferase expression
https://identifiers.org/aop.events/1698	Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor
https://identifiers.org/aop.events/1699	Decrease, expression of gonadotropin releasing hormone receptor
https://identifiers.org/aop.events/1703	Dysregulation of heart rate and vascular tone
https://identifiers.org/aop.events/1705	Impaired coordination and movement
https://identifiers.org/aop.events/173	N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
https://identifiers.org/aop.events/1738	SARS-CoV-2 cell entry
https://identifiers.org/aop.events/1740	Induced dysregulation of ACE2
https://identifiers.org/aop.events/1741	Induced, Angiotensin (Ang) II accumulation
https://identifiers.org/aop.events/1743	Increase plasma Ang II
https://identifiers.org/aop.events/1748	Increase, the risk of acute respiratory failure
https://identifiers.org/aop.events/1750	Increased inflammatory immune responses
https://identifiers.org/aop.events/1752	Increased Angiotensin II
https://identifiers.org/aop.events/1753	Chronic reactive oxygen species
https://identifiers.org/aop.events/1755	beta-catenin activation
https://identifiers.org/aop.events/1756	Decreased, plasma 11-ketotestosterone level
https://identifiers.org/aop.events/1757	Reduce, Sperm count
https://identifiers.org/aop.events/1758	Impaired, Spermatogenesis
https://identifiers.org/aop.events/176	Damaging, Mitochondria
https://identifiers.org/aop.events/1761	Inhibition, Fin regeneration
https://identifiers.org/aop.events/1762	Urothelial cell injury/death
https://identifiers.org/aop.events/1763	Urothelial Tumor
https://identifiers.org/aop.events/1765	Increase, Formation of DNA photoproducts
https://identifiers.org/aop.events/1766	Increase, DNA double-strand break
https://identifiers.org/aop.events/1767	Increase, Protein oxidation
https://identifiers.org/aop.events/1768	Increase, Abnormal osmoregulation
https://identifiers.org/aop.events/1769	Increase, Body fluid overload
https://identifiers.org/aop.events/177	N/A, Mitochondrial dysfunction 1
https://identifiers.org/aop.events/1770	Decrease, Mitochondrial membrane potential
https://identifiers.org/aop.events/1771	Decrease, Adenosine triphosphate pool
https://identifiers.org/aop.events/1772	Decrease, Neutral lipids
https://identifiers.org/aop.events/1773	Decrease, Global DNA methylation
https://identifiers.org/aop.events/1774	Increase, Caspase transcription
https://identifiers.org/aop.events/1775	Increase, Oocyte apoptosis
https://identifiers.org/aop.events/1776	Increase, Ovarian somatic cell apoptosis
https://identifiers.org/aop.events/1777	Increase, Ovarian follicle breakdown
https://identifiers.org/aop.events/1778	Decrease, Heritable DNA methylation (F3)
https://identifiers.org/aop.events/1779	Increase, Caspase transcription (F3)
https://identifiers.org/aop.events/178	Disruption, Mitochondrial electron transport chain
https://identifiers.org/aop.events/1780	Increase, Oocyte apoptosis (F3)
https://identifiers.org/aop.events/1781	Decrease, Fecundity (F3)
https://identifiers.org/aop.events/1782	Decrease, Oogenesis (F3)
https://identifiers.org/aop.events/1783	Increase, Ovarian somatic cell apoptosis (F3)
https://identifiers.org/aop.events/1784	Increase, Ovarian follicle breakdown (F3)
https://identifiers.org/aop.events/1785	Increase, Mitochondrial ATP synthase antagonism
https://identifiers.org/aop.events/1786	Nipple retention (NR), increased
https://identifiers.org/aop.events/1787	Downregulation, ACE2
https://identifiers.org/aop.events/1788	Status epilepticus
https://identifiers.org/aop.events/1789	Reduction, 17beta-estradiol synthesis by the undifferentiated gonad
https://identifiers.org/aop.events/179	Decreased, Mitochondrial fatty acid beta-oxidation
https://identifiers.org/aop.events/1790	Increased, Differentiation to Testis
https://identifiers.org/aop.events/1791	Increased, Male Biased Sex Ratio
https://identifiers.org/aop.events/1792	Toll-like receptor 4 activation
https://identifiers.org/aop.events/1793	Activator protein 1 activation
https://identifiers.org/aop.events/1794	Pin-1 activation
https://identifiers.org/aop.events/1795	Latent Transforming growth Factor beta expression
https://identifiers.org/aop.events/1796	11β-hydroxylase inhibition
https://identifiers.org/aop.events/1798	Decreased spermatogenesis
https://identifiers.org/aop.events/1799	Inhibition of 11β-HSD
https://identifiers.org/aop.events/1800	Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
https://identifiers.org/aop.events/1806	Inhibition, Chitinase
https://identifiers.org/aop.events/1807	Inhibition, Chitobiase
https://identifiers.org/aop.events/1814	benzoquinone imine and acylglucuronide metabolites
https://identifiers.org/aop.events/1815	Activation of ER stress
https://identifiers.org/aop.events/1816	Mitochondrial dysfunction
https://identifiers.org/aop.events/1817	Apoptotic cell death
https://identifiers.org/aop.events/1818	Immune cell activation
https://identifiers.org/aop.events/1819	IFNγ signaling
https://identifiers.org/aop.events/1820	Immune mediated hepatitis
https://identifiers.org/aop.events/1821	Decrease, Cell proliferation
https://identifiers.org/aop.events/1825	Increase, Cell death
https://identifiers.org/aop.events/1827	Increase, Global DNA methylation
https://identifiers.org/aop.events/1828	Increased, Thyroxine (T4) in serum
https://identifiers.org/aop.events/1829	Altered, Thyroid hormone-dependent gene expression
https://identifiers.org/aop.events/1830	Displacement, Serum thyroxine (T4) from carrier protein
https://identifiers.org/aop.events/1831	Binding, Thyroid binding globulin in serum
https://identifiers.org/aop.events/1834	Decrease, Acyl-CoA dehydrogenases
https://identifiers.org/aop.events/1835	Cortisol and 11β-(OH) testosterone decreased
https://identifiers.org/aop.events/1836	Decreased plasma Cortisol level
https://identifiers.org/aop.events/1837	decreased oocyte maturation
https://identifiers.org/aop.events/1839	Testicular Cancer
https://identifiers.org/aop.events/1840	Inhibition, cytochrome oxidase
https://identifiers.org/aop.events/1842	Prolonged TLR9 activation
https://identifiers.org/aop.events/1843	Multi Organ Failure involving Acute Respiratory Distress Syndrome
https://identifiers.org/aop.events/1844	systemic inflammatory response syndrome
https://identifiers.org/aop.events/1845	Coagulation
https://identifiers.org/aop.events/1846	Thrombosis and Disseminated Intravascular Coagulation
https://identifiers.org/aop.events/1847	Increased SARS-CoV-2 production
https://identifiers.org/aop.events/1849	Impaired gustatory nerve
https://identifiers.org/aop.events/185	Increase, Mutations
https://identifiers.org/aop.events/1850	dysgeusia
https://identifiers.org/aop.events/1851	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
https://identifiers.org/aop.events/1852	Increased Ang II type 1 receptor (AT1R)
https://identifiers.org/aop.events/1853	Hyperactivation of ACE/Ang-II/AT1R axis
https://identifiers.org/aop.events/1854	Dysregulation, ACE2 expression and activity
https://identifiers.org/aop.events/188	Neuroinflammation
https://identifiers.org/aop.events/192	Altered, Neurophysiology
https://identifiers.org/aop.events/193	Decreased, Nitric Oxide
https://identifiers.org/aop.events/195	Inhibition, NMDARs
https://identifiers.org/aop.events/202	Inhibition, Nuclear factor kappa B (NF-kB)
https://identifiers.org/aop.events/209	Peptide Oxidation
https://identifiers.org/aop.events/21	Altered regulation, Alpha hemoglobin
https://identifiers.org/aop.events/211	Propagation, Oxidative stress
https://identifiers.org/aop.events/213	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
https://identifiers.org/aop.events/214	Bile accumulation, Pathological condition
https://identifiers.org/aop.events/216	Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
https://identifiers.org/aop.events/219	Reduction, Plasma 17beta-estradiol concentrations
https://identifiers.org/aop.events/220	Increase, Plasma vitellogenin concentrations
https://identifiers.org/aop.events/221	Reduction, Plasma vitellogenin concentrations
https://identifiers.org/aop.events/227	Activation, PPARα
https://identifiers.org/aop.events/228	peroxisome proliferator activated receptor promoter demethylation
https://identifiers.org/aop.events/231	Decreased, PPAR-alpha activation
https://identifiers.org/aop.events/232	Decreased, PPAR-beta activation
https://identifiers.org/aop.events/233	Decreased, PPAR-gamma activation
https://identifiers.org/aop.events/239	Activation, Pregnane-X receptor, NR1l2
https://identifiers.org/aop.events/240	Feminisation or incomplete development, Primary and accessory male sex organs
https://identifiers.org/aop.events/243	Reduction, Prostaglandin E2 concentration
https://identifiers.org/aop.events/244	Alkylation, Protein
https://identifiers.org/aop.events/245	Activation, PXR/SXR
https://identifiers.org/aop.events/246	Increase, RBC congestion in liver
https://identifiers.org/aop.events/249	Production, Reactive oxygen species
https://identifiers.org/aop.events/25	Agonism, Androgen receptor
https://identifiers.org/aop.events/250	Damaging, Red blood cells; hemolysis
https://identifiers.org/aop.events/252	Increase, Renal pathology due to VTG deposition
https://identifiers.org/aop.events/253	N/A, Reproductive failure
https://identifiers.org/aop.events/257	Increase, Reactive Oxygen Species production
https://identifiers.org/aop.events/265	Activation, Stellate cells
https://identifiers.org/aop.events/266	Decrease, Steroidogenic acute regulatory protein (STAR)
https://identifiers.org/aop.events/269	Induction, Sustained Cell Proliferation
https://identifiers.org/aop.events/27	N/A, Androgen receptor, Antagonism
https://identifiers.org/aop.events/270	Induction, Sustained Hepatotoxicity
https://identifiers.org/aop.events/274	Reduction, Testosterone synthesis by ovarian theca cells
https://identifiers.org/aop.events/285	Reduction, Vitellogenin synthesis in liver
https://identifiers.org/aop.events/288	Activation of specific nuclear receptors, Transcriptional change
https://identifiers.org/aop.events/289	Decrease, Translocator protein (TSPO)
https://identifiers.org/aop.events/291	Accumulation, Triglyceride
https://identifiers.org/aop.events/294	N/A, Unknown
https://identifiers.org/aop.events/295	Induction, Upregulation of glucuronyltransferase activity
https://identifiers.org/aop.events/3	Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
https://identifiers.org/aop.events/307	Increase, Vitellogenin synthesis in liver
https://identifiers.org/aop.events/309	Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
https://identifiers.org/aop.events/310	Alteration, Wnt pathway
https://identifiers.org/aop.events/313	Increase, Allergic Respiratory Hypersensitivity Response
https://identifiers.org/aop.events/317	Altered, Cardiovascular development/function
https://identifiers.org/aop.events/319	Loss, Cochlear function
https://identifiers.org/aop.events/321	N/A, Cyanosis occurs
https://identifiers.org/aop.events/323	Increased, Disease susceptibility
https://identifiers.org/aop.events/327	Accumulation, Fatty acid
https://identifiers.org/aop.events/328	Decrease, Fecundity
https://identifiers.org/aop.events/330	Decrease, Fertility
https://identifiers.org/aop.events/334	Promotion, Hepatocelluar carcinoma
https://identifiers.org/aop.events/336	Increase, Heritable mutations in offspring
https://identifiers.org/aop.events/337	N/A, Impairment of reproductive capacity
https://identifiers.org/aop.events/339	Altered, Larval development
https://identifiers.org/aop.events/341	Impairment, Learning and memory
https://identifiers.org/aop.events/344	N/A, Liver fibrosis
https://identifiers.org/aop.events/345	N/A, Liver Steatosis
https://identifiers.org/aop.events/347	Formation, Liver tumor
https://identifiers.org/aop.events/348	Malformation, Male reproductive tract
https://identifiers.org/aop.events/351	Increased Mortality
https://identifiers.org/aop.events/356	Increased, Oxidative damage
https://identifiers.org/aop.events/357	Cholestasis, Pathology
https://identifiers.org/aop.events/360	Decrease, Population growth rate
https://identifiers.org/aop.events/361	Decline, Population
https://identifiers.org/aop.events/363	Altered, Reproductive behaviour
https://identifiers.org/aop.events/364	Impaired development of, Reproductive organs
https://identifiers.org/aop.events/373	Formation, Pro-mutagenic DNA Adducts
https://identifiers.org/aop.events/376	Increased, Induced Mutations in Critical Genes
https://identifiers.org/aop.events/378	Tumorigenesis, Hepatocellular carcinoma
https://identifiers.org/aop.events/382	Aberrant, Dendritic morphology
https://identifiers.org/aop.events/383	Reduced, Presynaptic release of glutamate
https://identifiers.org/aop.events/386	Decrease of neuronal network function
https://identifiers.org/aop.events/388	Overactivation, NMDARs
https://identifiers.org/aop.events/39	Increased Cholinergic Signaling
https://identifiers.org/aop.events/396	Covalent Binding, Protein
https://identifiers.org/aop.events/398	Activation, Dendritic Cells
https://identifiers.org/aop.events/40	Decrease, Mitochondrial ATP production
https://identifiers.org/aop.events/402	Cognitive Function, Decreased
https://identifiers.org/aop.events/403	Suppression, Immune system
https://identifiers.org/aop.events/405	irregularities, ovarian cycle
https://identifiers.org/aop.events/406	impaired, Fertility
https://identifiers.org/aop.events/409	Metabolism of AFB1, Production of Reactive Electrophiles
https://identifiers.org/aop.events/413	Reduction, Testosterone synthesis in Leydig cells
https://identifiers.org/aop.events/414	Increase, Luteinizing hormone (LH)
https://identifiers.org/aop.events/415	Hyperplasia, Leydig cell
https://identifiers.org/aop.events/416	Increase proliferation, Leydig cell
https://identifiers.org/aop.events/417	skewed, sex ratio
https://identifiers.org/aop.events/418	Increased, Vitellogenin synthesis
https://identifiers.org/aop.events/419	Increased, renal vitellogenin deposition
https://identifiers.org/aop.events/421	Increased, glomerular rupture and renal hemorrhaging
https://identifiers.org/aop.events/422	Increased, nephropathy
https://identifiers.org/aop.events/442	Decreased, Population trajectory
https://identifiers.org/aop.events/444	Increased, Atrioventricular block and bradycardia
https://identifiers.org/aop.events/445	Respiratory distress/arrest
https://identifiers.org/aop.events/446	Reduction, testosterone level
https://identifiers.org/aop.events/447	Reduction, Cholesterol transport in mitochondria
https://identifiers.org/aop.events/450	Suppression, VLDL secretion
https://identifiers.org/aop.events/451	Inhibition, Mitochondrial fatty acid beta-oxidation
https://identifiers.org/aop.events/454	Increased, Triglyceride formation
https://identifiers.org/aop.events/455	Accumulation, Liver lipid
https://identifiers.org/aop.events/456	Suppression, Constitutive androstane receptor, NR1l3
https://identifiers.org/aop.events/457	Activation, SREBF1
https://identifiers.org/aop.events/458	Increased, De Novo FA synthesis
https://identifiers.org/aop.events/459	Increased, Liver Steatosis
https://identifiers.org/aop.events/46	Accumulation, Biological membranes
https://identifiers.org/aop.events/461	Suppression, HNF4alpha
https://identifiers.org/aop.events/462	Up Regulation, SCD-1
https://identifiers.org/aop.events/463	Up Regulation, FAS
https://identifiers.org/aop.events/465	Increased, FA Influx
https://identifiers.org/aop.events/466	Up Regulation, LDLR (low density lipoprotein receptor)
https://identifiers.org/aop.events/467	Increased, LDL uptake
https://identifiers.org/aop.events/468	Inhibition, PPAR alpha
https://identifiers.org/aop.events/470	Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
https://identifiers.org/aop.events/471	Inhibition, FoxA2
https://identifiers.org/aop.events/472	Down Regulation, CPT1A
https://identifiers.org/aop.events/474	Down Regulation, HMGCS2
https://identifiers.org/aop.events/477	Decreased, Ketogenesis
https://identifiers.org/aop.events/478	Activation, NRF2
https://identifiers.org/aop.events/479	Activation, NR1H4
https://identifiers.org/aop.events/480	Activation, SHP
https://identifiers.org/aop.events/482	Decreased, DHB4/HSD17B4
https://identifiers.org/aop.events/483	Activation, LXR alpha
https://identifiers.org/aop.events/484	Activation, AKT2
https://identifiers.org/aop.events/486	systemic inflammation leading to hepatic steatosis
https://identifiers.org/aop.events/488	Decrease, Ovulation
https://identifiers.org/aop.events/49	Reduction, Ca and HCO3 transport to shell gland
https://identifiers.org/aop.events/491	Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
https://identifiers.org/aop.events/493	Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
https://identifiers.org/aop.events/494	Glucocorticoid Receptor Agonist, Activation
https://identifiers.org/aop.events/495	Repressed expression of steroidogenic enzymes
https://identifiers.org/aop.events/496	Increased apoptosis, decreased number of adult Leydig Cells
https://identifiers.org/aop.events/50	Increase, Ca++ (intracellular)
https://identifiers.org/aop.events/505	Decreased sperm quantity / quality in the adult, Decreased fertility
https://identifiers.org/aop.events/52	Decreased, Calcium influx
https://identifiers.org/aop.events/520	Decreased sperm quantity or quality in the adult, Decreased fertility
https://identifiers.org/aop.events/525	Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
https://identifiers.org/aop.events/526	Inhibition, Inhibition of Dopamine-beta-hydroxylase
https://identifiers.org/aop.events/527	Decreased, Decreased fecundity
https://identifiers.org/aop.events/528	Decreased, Synthesis of NE
https://identifiers.org/aop.events/529	Decreased, GnRH cfos activity
https://identifiers.org/aop.events/530	Decreased, GnRH pulsatility/release
https://identifiers.org/aop.events/531	Decreased, LH Surge
https://identifiers.org/aop.events/532	Delayed, Ovulation
https://identifiers.org/aop.events/533	Decreased, Cortical granule release/distribution upon fertilization
https://identifiers.org/aop.events/534	Altered, Formation of cortical envelope
https://identifiers.org/aop.events/535	Abnormal, Sperm penetration (polyspermy)
https://identifiers.org/aop.events/536	Altered, Chromosome number (polyploid) zygote
https://identifiers.org/aop.events/540	Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
https://identifiers.org/aop.events/541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
https://identifiers.org/aop.events/543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
https://identifiers.org/aop.events/55	Cell injury/death
https://identifiers.org/aop.events/559	Activation, Nicotinic acetylcholine receptor
https://identifiers.org/aop.events/560	Abnormal, Foraging activity and behavior
https://identifiers.org/aop.events/561	Reduced, Food storage
https://identifiers.org/aop.events/563	Death/Failure, Colony
https://identifiers.org/aop.events/564	Abnormal, Roll change within caste
https://identifiers.org/aop.events/565	Reduced, Brood care
https://identifiers.org/aop.events/566	impaired, Larval development
https://identifiers.org/aop.events/568	impaired, Hive thermoregulation
https://identifiers.org/aop.events/57	Proliferation, Cell proliferation in the absence of cytotoxicity
https://identifiers.org/aop.events/570	Accumulation, Damaged mitochondrial DNA
https://identifiers.org/aop.events/571	Accelerated, Aging
https://identifiers.org/aop.events/572	Decrease, Number of worker bees
https://identifiers.org/aop.events/573	Increase, Energetic demands and therefore metabolic stress
https://identifiers.org/aop.events/574	Increased, Appetite and hunger
https://identifiers.org/aop.events/576	Increased, Viral susceptibility
https://identifiers.org/aop.events/577	impaired, Development
https://identifiers.org/aop.events/578	Decreased, Glucose oxidase enzyme activity
https://identifiers.org/aop.events/579	Decreased, Hydrogen peroxide production
https://identifiers.org/aop.events/580	Reduced, Antiseptic incorporated in food
https://identifiers.org/aop.events/585	Decreased, Sodium conductance 1
https://identifiers.org/aop.events/586	Reduced, swimming speed
https://identifiers.org/aop.events/587	Reduced, feeding 1
https://identifiers.org/aop.events/588	Increased, predation
https://identifiers.org/aop.events/590	N/A, hypoxia
https://identifiers.org/aop.events/591	Increased, amputations
https://identifiers.org/aop.events/592	Reduced, survival
https://identifiers.org/aop.events/593	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
https://identifiers.org/aop.events/598	modulation, sodium channel
https://identifiers.org/aop.events/599	prolonged, Depolarization of neuronal membrane
https://identifiers.org/aop.events/600	Overactivation, Neuronotransmitter release
https://identifiers.org/aop.events/601	Overactivation, muscle contraction
https://identifiers.org/aop.events/602	Increased, Ataxia, paralysis, or hyperactivity
https://identifiers.org/aop.events/613	Occurrence, Epileptic seizure
https://identifiers.org/aop.events/616	Occurrence, A paroxysmal depolarizing shift
https://identifiers.org/aop.events/618	Decreased, Neuronal network function in adult brain
https://identifiers.org/aop.events/621	Increase, cilia movement
https://identifiers.org/aop.events/622	Increased, locomotion
https://identifiers.org/aop.events/623	Increase, predation
https://identifiers.org/aop.events/624	Increased, foot detachment
https://identifiers.org/aop.events/625	Increased, muscular waves in foot
https://identifiers.org/aop.events/626	Increased, serotonin (5-HT)
https://identifiers.org/aop.events/627	Decreased, anxiety
https://identifiers.org/aop.events/629	Decreased, sheltering
https://identifiers.org/aop.events/633	Decrease, histaminergic neuron excitation
https://identifiers.org/aop.events/634	N/A, sedation
https://identifiers.org/aop.events/635	Decreased, locomotion
https://identifiers.org/aop.events/636	Decreased, survival
https://identifiers.org/aop.events/638	Antagonism, Histamine Receptor (H2)
https://identifiers.org/aop.events/64	Reduction, Ionotropic GABA receptor chloride channel conductance
https://identifiers.org/aop.events/640	Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
https://identifiers.org/aop.events/642	Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
https://identifiers.org/aop.events/643	Decreased Cholesterol, Decreased Uptake of Lipoproteins
https://identifiers.org/aop.events/644	Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
https://identifiers.org/aop.events/645	Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells
https://identifiers.org/aop.events/646	Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
https://identifiers.org/aop.events/647	Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells
https://identifiers.org/aop.events/648	Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
https://identifiers.org/aop.events/649	Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
https://identifiers.org/aop.events/650	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
https://identifiers.org/aop.events/651	Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
https://identifiers.org/aop.events/652	Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
https://identifiers.org/aop.events/653	Decreased testosterone by the fetal Leydig cells, Increased corticosterone
https://identifiers.org/aop.events/654	Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
https://identifiers.org/aop.events/655	Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
https://identifiers.org/aop.events/656	Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
https://identifiers.org/aop.events/657	Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
https://identifiers.org/aop.events/658	Decreased testosterone by the fetal Leydig cells, Increased estradiol
https://identifiers.org/aop.events/659	Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
https://identifiers.org/aop.events/660	decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
https://identifiers.org/aop.events/661	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
https://identifiers.org/aop.events/662	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
https://identifiers.org/aop.events/664	Overwhelmed, Mitochondrial DNA repair mechanisms
https://identifiers.org/aop.events/667	Binding at picrotoxin site, iGABAR chloride channel
https://identifiers.org/aop.events/671	Reduced, Prostaglandin F2alpha concentration, plasma
https://identifiers.org/aop.events/672	Reduced, Prostaglandin F2alpha synthesis, ovary
https://identifiers.org/aop.events/673	Reduced, Spawning behavior
https://identifiers.org/aop.events/674	Reduced, Ability to attract spawning mates
https://identifiers.org/aop.events/675	Reduced, Reproductive Success
https://identifiers.org/aop.events/678	Reduced, Pheromone release
https://identifiers.org/aop.events/679	Decline, Population trajectory
https://identifiers.org/aop.events/68	Accumulation, Collagen
https://identifiers.org/aop.events/681	Decreased, Prostaglandin F2alpha synthesis, ovary
https://identifiers.org/aop.events/682	Generation, Amplified excitatory postsynaptic potential (EPSP)
https://identifiers.org/aop.events/685	Reduced, Prostaglandins, ovary
https://identifiers.org/aop.events/687	Reduced, Prostaglandin E2 concentration, hypothalamus
https://identifiers.org/aop.events/689	Reduced, Gonadotropin releasing hormone, hypothalamus
https://identifiers.org/aop.events/690	Reduced, Luteinizing hormone (LH), plasma
https://identifiers.org/aop.events/691	Reduced, Maturation inducing steroid, plasma
https://identifiers.org/aop.events/692	Reduced, Maturation inducing steroid receptor signalling, oocyte
https://identifiers.org/aop.events/693	Increased, cyclic adenosine monophosphate
https://identifiers.org/aop.events/694	Reduced, Meiotic prophase I/metaphase I transition, oocyte
https://identifiers.org/aop.events/695	Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
https://identifiers.org/aop.events/696	Increased, Chromosome misseggregation
https://identifiers.org/aop.events/697	impaired, ion channels
https://identifiers.org/aop.events/698	Altered, Action Potential
https://identifiers.org/aop.events/699	Increased, cardiac arrthymia
https://identifiers.org/aop.events/708	Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
https://identifiers.org/aop.events/709	Increase, Cytotoxicity (renal tubular cell)
https://identifiers.org/aop.events/710	Increase, Regenerative cell proliferation (tubular epithelial cells)
https://identifiers.org/aop.events/713	Increase, Adenomas/carcinomas (renal tubular)
https://identifiers.org/aop.events/714	Increased, Binding of chemicals to 2u (serum)
https://identifiers.org/aop.events/718	Binding, Tubulin
https://identifiers.org/aop.events/719	Increase, hepatocellular adenomas and carcinomas
https://identifiers.org/aop.events/720	Disruption, Microtubule dynamics
https://identifiers.org/aop.events/721	Disorganization, Meiotic Spindle
https://identifiers.org/aop.events/723	Altered, Chromosome number
https://identifiers.org/aop.events/724	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
https://identifiers.org/aop.events/726	Increased, Induction of pyruvate dehydrogenase (PDH)
https://identifiers.org/aop.events/728	Increase, Aneuploid offspring
https://identifiers.org/aop.events/733	Increase, Necrosis (terminal bronchiolar cells)
https://identifiers.org/aop.events/734	Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
https://identifiers.org/aop.events/735	Increase, Hyperplasia (terminal bronchiolar cells)
https://identifiers.org/aop.events/736	Increase, Adenomas/carcinomas (bronchioloalveolar)
https://identifiers.org/aop.events/739	Increase, Hypertrophy and proliferation (follicular cell)
https://identifiers.org/aop.events/740	Increase, Hyperplasia (follicular cells)
https://identifiers.org/aop.events/741	Increase, Adenomas/carcinomas (follicular cell)
https://identifiers.org/aop.events/742	Decreased, Androgen receptor activity
https://identifiers.org/aop.events/743	Decreased, Testosterone binding to androgen receptor (hypothalamus)
https://identifiers.org/aop.events/744	Increase, Hyperplasia (Leydig cells)
https://identifiers.org/aop.events/745	Increase, Leydig cell tumors
https://identifiers.org/aop.events/746	Increase, Dopaminergic activity
https://identifiers.org/aop.events/747	Decreased, Prolactin
https://identifiers.org/aop.events/748	Increased, Estrogen receptor (ER) activity
https://identifiers.org/aop.events/749	Decreased, Progesterone from corpus luteum
https://identifiers.org/aop.events/754	Increased, Luteinizing hormone (LH)
https://identifiers.org/aop.events/756	Hippocampal gene expression, Altered
https://identifiers.org/aop.events/757	Hippocampal anatomy, Altered
https://identifiers.org/aop.events/758	Hippocampal Physiology, Altered
https://identifiers.org/aop.events/759	Increased, Kidney Failure
https://identifiers.org/aop.events/760	Activation, Glutamate-gated chloride channel
https://identifiers.org/aop.events/761	Increased, Chloride conductance
https://identifiers.org/aop.events/762	Activation, ionotropic GABA Receptor chloride channel
https://identifiers.org/aop.events/763	hyperpolarisation, neuron
https://identifiers.org/aop.events/764	N/A, Ataxia, paralysis, or hyperactivity
https://identifiers.org/aop.events/765	Decreased, population 1
https://identifiers.org/aop.events/766	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
https://identifiers.org/aop.events/767	Increase, Hyperplasia (renal tubular cells)
https://identifiers.org/aop.events/768	Increase, Cytotoxicity
https://identifiers.org/aop.events/769	Increase, Oxidative metabolism
https://identifiers.org/aop.events/77	Production, Critical Metabolites (CGA 330050 and CGA 265307)
https://identifiers.org/aop.events/770	Increase, Cytotoxicity (club cells)
https://identifiers.org/aop.events/771	Decrease, Serum thyroid hormone (T4/T3)
https://identifiers.org/aop.events/772	Increase, Hyperplasia (glandular epithelial cells of endometrium)
https://identifiers.org/aop.events/773	Increase, Endometrial adenocarcinomas
https://identifiers.org/aop.events/774	Increase, Preneoplastic foci (hepatocytes)
https://identifiers.org/aop.events/775	Increased, Plasma tyrosine
https://identifiers.org/aop.events/776	Increase, Cytotoxicity (corneal cells)
https://identifiers.org/aop.events/777	Increase, Inflammation (corneal cells)
https://identifiers.org/aop.events/778	Increase, Regenerative cell proliferation (corneal cells)
https://identifiers.org/aop.events/779	Increase, Papillomas/carcinomas (squamous cells)
https://identifiers.org/aop.events/78	Reduction, Cumulative fecundity and spawning
https://identifiers.org/aop.events/780	Increase, Cytotoxicity (epithelial cells)
https://identifiers.org/aop.events/781	Increase, Regenerative cell proliferation (forestomach epithelial cells)
https://identifiers.org/aop.events/782	Increase, Hyperplasia (forestomach epithelial cells)
https://identifiers.org/aop.events/783	Increase, Cytotoxicity (tubular epithelial cells)
https://identifiers.org/aop.events/784	Increase, Hyperplasia (tubular epithelial cells)
https://identifiers.org/aop.events/785	Activation, Androgen receptor
https://identifiers.org/aop.events/786	Increase, Cytotoxicity (hepatocytes)
https://identifiers.org/aop.events/787	Increase, Regenerative cell proliferation (hepatocytes)
https://identifiers.org/aop.events/790	Inhibition, 5α-reductase activity
https://identifiers.org/aop.events/791	Increased, Leutinizing hormone (LH)
https://identifiers.org/aop.events/792	Decrease, Bioactivation of testosterone
https://identifiers.org/aop.events/793	Increase, Urinary bladder calculi
https://identifiers.org/aop.events/794	Increase, Cytotoxicity (urothelial cells)
https://identifiers.org/aop.events/795	Increase, Regenerative cell proliferation (urothelial cells)
https://identifiers.org/aop.events/796	Increase, Hyperplasia (urothelial)
https://identifiers.org/aop.events/797	Increase, Adenomas/carcinomas (urothelial)
https://identifiers.org/aop.events/798	Inhibition, Prolyl hydroxylases
https://identifiers.org/aop.events/799	Increased, HIF-1 heterodimer
https://identifiers.org/aop.events/8	Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
https://identifiers.org/aop.events/80	Up Regulation, CYP1A1
https://identifiers.org/aop.events/800	Decreased, Aromatase (Cyp19a1) mRNA
https://identifiers.org/aop.events/801	modulation, Unknown
https://identifiers.org/aop.events/802	Increased, HIF-1 alpha transcription
https://identifiers.org/aop.events/804	Inhibition, HMG-CoA reductase
https://identifiers.org/aop.events/805	Decreased, mevalonate
https://identifiers.org/aop.events/807	Decreased, cholesterol
https://identifiers.org/aop.events/808	Decreased, Testosterone
https://identifiers.org/aop.events/809	malformed, Male reproductive tract
https://identifiers.org/aop.events/813	Increased, Serum creatinine
https://identifiers.org/aop.events/814	Occurrence, Kidney toxicity
https://identifiers.org/aop.events/818	Occurrence, Cytoplasmic vacuolization (Renal tubule)
https://identifiers.org/aop.events/819	Decreased, Glomerular filtration
https://identifiers.org/aop.events/820	Decreased, Renal plasma flow
https://identifiers.org/aop.events/821	Decreased, Sodium reabsorption
https://identifiers.org/aop.events/823	Occurrence, Cystic dilatation (renal tubule)
https://identifiers.org/aop.events/824	Occurrence, Cytoplasmic vacuolization (podocyte)
https://identifiers.org/aop.events/825	Decreased, Renal ability to dilute urine
https://identifiers.org/aop.events/827	sensitisation, skin
https://identifiers.org/aop.events/828	Inhibition, Phospholipase A
https://identifiers.org/aop.events/829	Damage, Lipid bilayer
https://identifiers.org/aop.events/831	Disturbance, Lysosomal function
https://identifiers.org/aop.events/832	Injury, Mitochondria
https://identifiers.org/aop.events/833	Occurrence, Cytoplasmic vacuolization (hepatocyte)
https://identifiers.org/aop.events/835	Occurrence, Ballooning degeneration (hepatocyte)
https://identifiers.org/aop.events/836	Occurrence, Cytoplasmic vacuolization (Bile duct cell)
https://identifiers.org/aop.events/837	Occurrence, Cytoplasmic vacuolization (kupffer cell)
https://identifiers.org/aop.events/838	Induction, Microvesicular fat
https://identifiers.org/aop.events/839	Formation, Mallory body
https://identifiers.org/aop.events/840	Formation, Liver fibrosis
https://identifiers.org/aop.events/844	Oxidation, Uroporphyrinogen
https://identifiers.org/aop.events/845	Inhibition, UROD
https://identifiers.org/aop.events/846	Accumulation, Highly carboxylated porphyrins
https://identifiers.org/aop.events/848	Decreased, Binding of NE to NE receptors on GnRH neurons
https://identifiers.org/aop.events/849	Inhibition, Antgonism of NE receptor
https://identifiers.org/aop.events/850	Induction, CYP1A2/CYP1A5
https://identifiers.org/aop.events/854	Alterations, Cellular proliferation / hyperplasia
https://identifiers.org/aop.events/860	Decreased, Mitochondrial Fatty Acid Beta Oxidation
https://identifiers.org/aop.events/861	Decreased, Ketogenesis (production of ketone bodies)
https://identifiers.org/aop.events/862	Not Increased, Circulating Ketone Bodies
https://identifiers.org/aop.events/863	Increased, Catabolism of Muscle Protein
https://identifiers.org/aop.events/864	Decreased, Body Weight
https://identifiers.org/aop.events/867	Decrease, Intracellular pH
https://identifiers.org/aop.events/868	Increase, Tissue Degeneration, Necrosis & Atrophy
https://identifiers.org/aop.events/869	Increase, Respiratory or Squamous Metaplasia
https://identifiers.org/aop.events/87	Release, Cytokine
https://identifiers.org/aop.events/870	Increase, Cell Proliferation
https://identifiers.org/aop.events/872	Increase, Site of Contact Nasal Tumors
https://identifiers.org/aop.events/875	Binding of agonist, Ionotropic glutamate receptors
https://identifiers.org/aop.events/876	Increase, Mutations in Critical Genes
https://identifiers.org/aop.events/878	Inhibition, SREBP1c
https://identifiers.org/aop.events/879	Activation, MTTP
https://identifiers.org/aop.events/880	Increased, ApoB100
https://identifiers.org/aop.events/881	Increased, Triglyceride
https://identifiers.org/aop.events/885	Increase, Cancer
https://identifiers.org/aop.events/889	Impaired, Proteostasis
https://identifiers.org/aop.events/890	Degeneration of dopaminergic neurons of the nigrostriatal pathway
https://identifiers.org/aop.events/896	Parkinsonian motor deficits
https://identifiers.org/aop.events/898	Disruption, Lysosome
https://identifiers.org/aop.events/9	Activation, 5HT2c
https://identifiers.org/aop.events/926	Oxidation, Glutathione (To be considered with MIE)
https://identifiers.org/aop.events/932	KE4 : Uncoupling, eNOS
https://identifiers.org/aop.events/933	KE6 : Depletion, Nitric Oxide
https://identifiers.org/aop.events/934	KE3 : Decrease, Tetrahydrobiopterin
https://identifiers.org/aop.events/937	KE7 : Impaired, Vasodilation
https://identifiers.org/aop.events/945	reduced dimerization, ARNT/HIF1-alpha
https://identifiers.org/aop.events/947	Increase, Early Life Stage Mortality
https://identifiers.org/aop.events/951	KE8 : Increase, Vascular Resistance
https://identifiers.org/aop.events/952	Hypertension
https://identifiers.org/aop.events/964	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
https://identifiers.org/aop.events/965	reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells
https://identifiers.org/aop.events/966	Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation
https://identifiers.org/aop.events/967	Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus
https://identifiers.org/aop.events/968	Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response
https://identifiers.org/aop.events/969	Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons
https://identifiers.org/aop.events/97	Alkylation, DNA
https://identifiers.org/aop.events/970	Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs
https://identifiers.org/aop.events/971	Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
https://identifiers.org/aop.events/972	Decreased fertility, Reduced number of oocytes ovulated
https://identifiers.org/aop.events/986	Impairment of TDAR
https://identifiers.org/aop.events/988	Decrease, Circulating ecdysis triggering hormone
https://identifiers.org/aop.events/990	Increase, Incomplete ecdysis
https://identifiers.org/aop.events/993	Decrease, Abdominal muscle contraction
https://identifiers.org/aop.events/996	Decrease, Digestion of old cuticle
https://identifiers.org/aop.events/998	Binding of antagonist, PPAR alpha
https://identifiers.org/aop.events/1895	NLRP3 inflammasome activity, increased
https://identifiers.org/aop.events/1864	Increase, Programmed cell death
https://identifiers.org/aop.events/1555	Increase cell proliferation
https://identifiers.org/aop.events/17	Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
https://identifiers.org/aop.events/1857	Platelet-neutrophil interactions, Increased
https://identifiers.org/aop.events/1866	Fibrinolysis, decreased
https://identifiers.org/aop.events/1867	Bradykinin system, hyperactivated
https://identifiers.org/aop.events/1869	Diminished protective oxidative stress response
https://identifiers.org/aop.events/1875	Cerebrovascular disease (stroke)
https://identifiers.org/aop.events/1881	Decreased, all-trans retinoic acid (atRA) concentration
https://identifiers.org/aop.events/1901	Interferon-I antiviral response, antagonized by SARS-CoV-2
https://identifiers.org/aop.events/1902	Repression of Gbx2 expression
https://identifiers.org/aop.events/1906	Cystic Fibrosis Transmembrane Regulator Function, Decreased
https://identifiers.org/aop.events/1907	Airway Surface Liquid Height, Decreased
https://identifiers.org/aop.events/1908	Cilia Beat Frequency, Decreased
https://identifiers.org/aop.events/1909	Mucociliary Clearance, Decreased
https://identifiers.org/aop.events/1911	FOXJ1 Protein, Decreased
https://identifiers.org/aop.events/1912	Motile Cilia Number/Length, Decreased
https://identifiers.org/aop.events/1939	Viral infection and host-to-host transmission, proliferated
https://identifiers.org/aop.events/1967	Pyroptosis
https://identifiers.org/aop.events/1970	transposition of the great arteries
https://identifiers.org/aop.events/1981	Decreased SIRT1 expression
https://identifiers.org/aop.events/1008	Reduced, Hearing
https://identifiers.org/aop.events/105	Inhibition, Mitochondrial Electron Transport Chain Complexes
https://identifiers.org/aop.events/1550	Deposition of Ionizing Energy
https://identifiers.org/aop.events/1607	Increase, Necrosis
https://identifiers.org/aop.events/1647	GSK3beta inactivation
https://identifiers.org/aop.events/1809	Increase, Tissue/organ damage
https://identifiers.org/aop.events/1855	Increased Sodium-sensitive hypertension
https://identifiers.org/aop.events/1856	Imbalanced salty and sweet taste responses
https://identifiers.org/aop.events/1861	Increase, D1 protein deactivation
https://identifiers.org/aop.events/1862	Decrease, Photosystem II efficiency
https://identifiers.org/aop.events/1863	Decrease, Reproduction
https://identifiers.org/aop.events/1865	Increase, Oxygen-evolving complex damage
https://identifiers.org/aop.events/1868	Hyperinflammation
https://identifiers.org/aop.events/1870	Sustentacular cells, decrease
https://identifiers.org/aop.events/1871	olfactory sensory neurons, decrease
https://identifiers.org/aop.events/1872	Olfactory epithelium degeneration
https://identifiers.org/aop.events/1873	impaired olfactory function (anosmia)
https://identifiers.org/aop.events/1874	blood brain barrier disruption
https://identifiers.org/aop.events/1877	Altered, retinal layer structure
https://identifiers.org/aop.events/1878	Decreased, Eye size
https://identifiers.org/aop.events/1879	Bulky DNA adducts, increase
https://identifiers.org/aop.events/1880	Inhibition of ALDH1A (RALDH)
https://identifiers.org/aop.events/1882	Disrupted meiotic initiation of fetal oogonia of the ovary
https://identifiers.org/aop.events/1883	Reduced size of the ovarian follicle pool
https://identifiers.org/aop.events/1884	Inhibition of Fyna
https://identifiers.org/aop.events/1885	Inhibition of Plxna2
https://identifiers.org/aop.events/1886	Overexpression of rasl11b
https://identifiers.org/aop.events/1888	Increased (ectopic) all-trans retinoic acid concentration
https://identifiers.org/aop.events/1889	Premature initiation of meiosis in fetal male germ cells
https://identifiers.org/aop.events/1890	Decrease (loss of) fetal male germ cells
https://identifiers.org/aop.events/1891	abnormal, placental labyrinth vasculature morphology
https://identifiers.org/aop.events/1892	increase, placental insufficiency
https://identifiers.org/aop.events/1893	increase, Preeclampsia
https://identifiers.org/aop.events/1896	Genomic instability
https://identifiers.org/aop.events/1897	increased MyD88 activation
https://identifiers.org/aop.events/1898	increased release of danger/damage associated molecular patterns
https://identifiers.org/aop.events/1899	formation of neutrophil extracellular traps (NETs)
https://identifiers.org/aop.events/1900	increased platelet surface TLR9 expression
https://identifiers.org/aop.events/1903	foxi1 expression, increased
https://identifiers.org/aop.events/1904	six1b expression, increased
https://identifiers.org/aop.events/1905	eya1 expression, inhibited
https://identifiers.org/aop.events/1913	Endothelial cell dysfunction
https://identifiers.org/aop.events/1914	Platelet activation, Increased
https://identifiers.org/aop.events/1915	Neutrophil activation, Increased
https://identifiers.org/aop.events/1916	Thromboinflammation, Increased
https://identifiers.org/aop.events/1917	Altered gene expression, NRF2 dependent antioxidant pathway
https://identifiers.org/aop.events/1920	Altered gene expression, TGF-β dependent fibrosis pathway
https://identifiers.org/aop.events/1921	Altered gene expression, NF-kB dependent Interleukin-6 pathway
https://identifiers.org/aop.events/1922	Increased, Reactive metabolites production
https://identifiers.org/aop.events/1923	Altered gene expression, P53 dependent apoptosis pathway
https://identifiers.org/aop.events/1930	altered, inner ear development
https://identifiers.org/aop.events/1931	Intestinal barrier, disruption
https://identifiers.org/aop.events/1933	Increased, Interleukin-6 production
https://identifiers.org/aop.events/1934	Myocardial Infarction
https://identifiers.org/aop.events/1935	Angiotensin (1-7) levels diminished
https://identifiers.org/aop.events/1936	Angiotensin II degradation reduced
https://identifiers.org/aop.events/1937	ADAM17 expression induction
https://identifiers.org/aop.events/1938	ACE2 increased shedding
https://identifiers.org/aop.events/1940	Increases in cellular reactive oxygen species
https://identifiers.org/aop.events/1941	Memory Loss
https://identifiers.org/aop.events/1942	Accumulation, Cytosolic toxic Tau oligomers
https://identifiers.org/aop.events/1943	Hyperphosphorylation of Tau
https://identifiers.org/aop.events/1944	Synaptic dysfunction
https://identifiers.org/aop.events/1945	Dysfunctional Autophagy
https://identifiers.org/aop.events/1946	Impaired mechanotransduction of pericytes
https://identifiers.org/aop.events/1947	Pericyte dysfunction
https://identifiers.org/aop.events/1948	Increased ACE2 expression
https://identifiers.org/aop.events/1949	Decrease, GLUT4
https://identifiers.org/aop.events/1950	Increase, TNF
https://identifiers.org/aop.events/1951	Decrease, Glucose uptake
https://identifiers.org/aop.events/1952	Abnormal, Glucose homeostasis
https://identifiers.org/aop.events/1953	Gestational diabetes mellitus
https://identifiers.org/aop.events/1954	Gut microbiota, alteration
https://identifiers.org/aop.events/1955	Acute Myeloid Leukemia
https://identifiers.org/aop.events/1961	Prolongation of Action Potential Duration
https://identifiers.org/aop.events/1962	Prolongation of QT interval
https://identifiers.org/aop.events/1963	Torsades de Pointes
https://identifiers.org/aop.events/1964	Sudden cardiac death
https://identifiers.org/aop.events/1965	Increase, Pollen abnormal
https://identifiers.org/aop.events/1968	Increase, Mitochondrial Dysfunction
https://identifiers.org/aop.events/1969	Increase, Oxidative Stress
https://identifiers.org/aop.events/1971	Increased, tumor growth
https://identifiers.org/aop.events/1972	Increased, Steroidogenic acute regulatory protein (StAR)
https://identifiers.org/aop.events/1973	Increased, estrogens
https://identifiers.org/aop.events/1974	Activation of Tumor Protein 53
https://identifiers.org/aop.events/1977	Disruption of sodium channel gating kinetics
https://identifiers.org/aop.events/1978	Increase risk, microcephaly
https://identifiers.org/aop.events/1979	Premature cell differentiation
https://identifiers.org/aop.events/1980	Increased micro RNA expression
https://identifiers.org/aop.events/1982	metastatic breast cancer
https://identifiers.org/aop.events/1983	Disruption, action potential
https://identifiers.org/aop.events/902	Inflammation, Liver
https://identifiers.org/aop.events/997	Decreased, Population size
https://identifiers.org/aop.events/2020	Decrease, sox9 expression
https://identifiers.org/aop.events/2021	Increase, slincR expression
https://identifiers.org/aop.events/2024	Reduced complex sphingolipids
https://identifiers.org/aop.events/2027	Antagonism, Smoothened receptor
https://identifiers.org/aop.events/2040	Decrease, GLI1/2 target gene expression
https://identifiers.org/aop.events/2042	Ororofacial clefting
https://identifiers.org/aop.events/2043	Decrease, Sonic Hedgehog second messenger production
https://identifiers.org/aop.events/2044	Decrease, Smoothend relocation and activation
https://identifiers.org/aop.events/1299	Activation, AKT
https://identifiers.org/aop.events/1300	Activation, mTORC1
https://identifiers.org/aop.events/1310	Activation, PI3K
https://identifiers.org/aop.events/1554	Increase Chromosomal Aberrations
https://identifiers.org/aop.events/1985	Increased, Kisspeptin signalling
https://identifiers.org/aop.events/1986	Decreased, Gonadotropins
https://identifiers.org/aop.events/1987	Decreased, Androgen and Progestin
https://identifiers.org/aop.events/1988	Decreased, Maturation Inducing Steroid Surge by Granulosa cells
https://identifiers.org/aop.events/1989	Impaired, Oocyte maturation and ovulation
https://identifiers.org/aop.events/1990	Increased, Oocyte Atresia
https://identifiers.org/aop.events/1991	Impaired, Reproduction
https://identifiers.org/aop.events/1995	Abnormal lipid metabolism
https://identifiers.org/aop.events/2005	Altered neurotransmission in development
https://identifiers.org/aop.events/2006	Secondary genotoxicity
https://identifiers.org/aop.events/2007	Non-coding RNA expression profile alteration
https://identifiers.org/aop.events/2008	Chronic obstructive pulmonary disease
https://identifiers.org/aop.events/2009	Activation of inflammation pathway
https://identifiers.org/aop.events/2010	Pulmonary inflammation
https://identifiers.org/aop.events/2011	Emphysema
https://identifiers.org/aop.events/2012	Fibroblast proliferation and differentiation
https://identifiers.org/aop.events/2013	Airway remodeling
https://identifiers.org/aop.events/2017	Endoplasmic reticulum stress
https://identifiers.org/aop.events/2018	Insulin resistance
https://identifiers.org/aop.events/2019	Non-alcoholic fatty liver disease
https://identifiers.org/aop.events/2022	Altered function of the brain
https://identifiers.org/aop.events/2023	Inhibition of Ceramide Synthase
https://identifiers.org/aop.events/2025	Affected folate transporter
https://identifiers.org/aop.events/2026	decreased folate uptake
https://identifiers.org/aop.events/2028	Decrease, GLI1/2 translocation to nucleus
https://identifiers.org/aop.events/2029	protein-coupled estrogen receptor 1 (GPER) activation
https://identifiers.org/aop.events/2030	Activation, PARP1
https://identifiers.org/aop.events/2031	Releasing, Apoptosis-Inducing Factor (AIF)
https://identifiers.org/aop.events/2032	Viable offspring, decreased
https://identifiers.org/aop.events/2033	Increased sphingolipid-1-phosphate
https://identifiers.org/aop.events/2034	liver dysfunction
https://identifiers.org/aop.events/2036	Activation of metabotropic glutamate receptor
https://identifiers.org/aop.events/2037	Inositol triphosphate receptor activation
https://identifiers.org/aop.events/2038	Activation of calpain signalling
https://identifiers.org/aop.events/2039	Inhibition GABAA receptor
https://identifiers.org/aop.events/2041	Decrease, palatal shelf outgrowth
https://identifiers.org/aop.events/2045	Increase, Alcohol dehydrogenase
https://identifiers.org/aop.events/2046	Increase, Vitellogenin mRNA
https://identifiers.org/aop.events/2047	Delay, Ovarian maturation
https://identifiers.org/aop.events/2048	Increase, Body volume of female adults
https://identifiers.org/aop.events/2049	Increase, sex ratio (F/M)
https://identifiers.org/aop.events/2050	Increase, developmental abnormalities
https://identifiers.org/aop.events/2051	Decrease, Tyrosine
https://identifiers.org/aop.events/2052	Decrease, dopa decarboxylase
https://identifiers.org/aop.events/2053	Increase, Defects in tanning of new cuticle
https://identifiers.org/aop.events/2054	Increase, impairment of cuticle sclerotization
https://identifiers.org/aop.events/2055	Increase, pigmentation
https://identifiers.org/aop.events/2056	Increase, delay in oviposition
https://identifiers.org/aop.events/2057	Decrease, hatching of egg
https://identifiers.org/aop.events/2058	Decrease, 20-hydroxyecdysone
https://identifiers.org/aop.events/2059	Decrease, knickkopf gene
https://identifiers.org/aop.events/2060	Decrease, Chitin laminar organization
https://identifiers.org/aop.events/2061	Decrease, Prevent chitin degradation by chitinases
https://identifiers.org/aop.events/2062	Weak, Procuticle protection
https://identifiers.org/aop.events/2063	Decrease, New cuticle secretion
https://identifiers.org/aop.events/2064	Increase, Cytosolic calcium
https://identifiers.org/aop.events/2065	Inhibition, Fatty acid oxidation
https://identifiers.org/aop.events/2066	Altered Signaling Pathways
https://identifiers.org/aop.events/2067	Altered, Nitric Oxide Levels
https://identifiers.org/aop.events/2068	Increase, Endothelial Dysfunction
https://identifiers.org/aop.events/2096	Occurrence, (Micro)vascular dysfunction
https://identifiers.org/aop.events/1998	Activation, Microglia
https://identifiers.org/aop.events/2082	Hypospadias, increased
https://identifiers.org/aop.events/2084	Increase, Cardiac remodelling
https://identifiers.org/aop.events/2085	Alveolar epithelial injury
https://identifiers.org/aop.events/2086	Airway inflammation
https://identifiers.org/aop.events/2087	Increased incidence of respiratory disease
https://identifiers.org/aop.events/2088	Dysfunction of respiratory system
https://identifiers.org/aop.events/2089	Altered Bone Cell Homeostasis
https://identifiers.org/aop.events/2090	Increase, Bone Remodeling
https://identifiers.org/aop.events/2091	Occurrence, Bone Loss
https://identifiers.org/aop.events/2092	Promotion, Ovarian Cancer
https://identifiers.org/aop.events/2093	Brain thyroid hormone (T4/T3) decreased
https://identifiers.org/aop.events/2094	Abnormal, neuroblast migration
https://identifiers.org/aop.events/2095	Periventricular heterotopia formation
https://identifiers.org/aop.events/2097	Increase, Pro-Inflammatory Mediators
https://identifiers.org/aop.events/2098	Increase, Neural Remodeling
https://identifiers.org/aop.events/2099	hERG channel blockade
https://identifiers.org/aop.events/2100	Inhibition of rapid delayed rectifying potassium current
https://identifiers.org/aop.events/2104	Decreased, thyroid hormone binding to thyroid hormone receptor
https://identifiers.org/aop.events/2105	Decreased, myelin basic protein expression in oligodendrocytes
https://identifiers.org/aop.events/2106	Impaired, oligodendrocyte maturation
https://identifiers.org/aop.events/2107	Hypomyelination
https://identifiers.org/aop.events/2108	Altered, white brain matter
https://identifiers.org/aop.events/2109	Binding, extracellular matrix protein laminin
https://identifiers.org/aop.events/2110	Disrupted binding, laminin-beta1-integrin receptors with laminin
https://identifiers.org/aop.events/2111	Decreased, neural progenitor cell adhesion to laminin
https://identifiers.org/aop.events/2112	Disturbed, radial glia cell alignment and migration
https://identifiers.org/aop.events/2113	Decreased, radial glia cell density
https://identifiers.org/aop.events/2114	Disturbed, cortical architecture
https://identifiers.org/aop.events/2115	Altered, cholesterol metabolism
https://identifiers.org/aop.events/2116	Decreased, oligodendrocyte differentiation
https://identifiers.org/aop.events/2117	Increase, goblet cell number
https://identifiers.org/aop.events/2118	Succinate dehydrogenase, inhibited
https://identifiers.org/aop.events/130	Depletion, GSH
https://identifiers.org/aop.events/2119	Insulin resistance, increased
https://identifiers.org/aop.events/2120	Superoxide generation, increased
https://identifiers.org/aop.events/2121	decreased, Intellectual Quotient
https://identifiers.org/aop.events/2122	increased, Economic Burden
https://identifiers.org/aop.events/2123	decreased, Bcl-2 expression
https://identifiers.org/aop.events/2124	increased, Bax expression
https://identifiers.org/aop.events/2125	Increased fat mass
https://identifiers.org/aop.events/2126	Estrogen receptor alpha inactivation
https://identifiers.org/aop.events/2127	Increased adipocyte size
https://identifiers.org/aop.events/2128	Increased adipocyte numbers
https://identifiers.org/aop.events/2129	Metabolically unhealthy Obesity
https://identifiers.org/aop.events/2130	increased lipid accumulation
https://identifiers.org/aop.events/2131	Conjugation, Glutathione
https://identifiers.org/aop.events/2132	Increased pro-inflammatory cytokine expression

Code examples

curl

curl -o keyeventWithTitle.rq https://raw.githubusercontent.com/BiGCAT-UM/PRA3006-SPARQL/master/sparql/keyeventWithTitle.rq
curl -H "Accept: text/tab-separated-values" -G https://aopwiki.rdf.bigcat-bioinformatics.org/sparql --data-urlencode query@keyeventWithTitle.rq

This SPARQL query is available under CCZero.

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