This pathway depicts the metabolism of cobalamin (also known as cbl or Vit. B12) and related diseases (for a full overview of the B12 metabolism, see [https://www.wikipathways.org/index.php/Pathway:WP1533]). Vit. B12 is derived from food sources and thereafter metabolised for 2 reasons; 1. to methylate homocysteine to methionine, and 2. to convert methylmalonyl-CoA to succinyl-CoA. This pathway depicts 15 distinct diseases which are related to a malfunctioning in the absorption and transport section, or the intracellular processing of Cbl. However, the exact function of some proteins which have been linked to these diseases, remains unclear. Substitution of Vit. B12 is a therapeutic option for patients with absorption and transport related diseases, however does not perform so well for patient with intracellular processing defects. This pathway was inspired by Chapter 13 of the book of Blau (ISBN 3642403360 (978-3642403361)). [-:-] Unknown node in line: Comment [ARROW:af6b1] Invalid interaction type "ARROW" as an output from reaction. [ARROW:accbc] Invalid interaction type "ARROW" as an output from reaction. [ARROW:d2919] Invalid interaction type "ARROW" as an output from reaction. [ARROW:f7d6d] Invalid interaction type "ARROW" as an output from reaction. [ARROW:cafa8] Invalid interaction type "ARROW" as an output from reaction. [ARROW:bab2c] Invalid interaction type "ARROW" as an output from reaction. [ARROW:bd645] Invalid interaction type "ARROW" as an output from reaction. [ARROW:dd45f] Invalid interaction type "ARROW" as an output from reaction. [BINDING:d5f0f] Invalid interaction type as an input to reaction. [BINDING:id9fe7f3f6] Invalid interaction type as an input to reaction. [ARROW:bff4c] Invalid interaction type "ARROW" as an output from reaction. [ARROW:c0757] Invalid interaction type "ARROW" as an output from reaction. [ARROW:dac35] Invalid interaction type "ARROW" as an output from reaction. [ARROW:cafee] Invalid interaction type "ARROW" as an output from reaction. [ARROW:idbc64746a] Invalid interaction type "ARROW" as an output from reaction. [BINDING:ide9523c3b] Invalid interaction type as an input to reaction. [ARROW:cb237] Invalid interaction type "ARROW" as an output from reaction. [ARROW:a0e21] Invalid interaction type "ARROW" as an output from reaction. [BINDING:idf82ce25b] Invalid interaction type as an input to reaction. [ARROW:e0a02] Invalid interaction type "ARROW" as an output from reaction. [BINDING:idc87a833f] Invalid interaction type as an input to reaction. [Label:a8fce] Label cannot be part of reaction. Tranforming to Unknown [Label:dfad8] Label cannot be part of reaction. Tranforming to Unknown [Label:c4614] Label cannot be part of reaction. Tranforming to Unknown [Label:bd975] Label cannot be part of reaction. Tranforming to Unknown [Label:c1c5c] Label cannot be part of reaction. Tranforming to Unknown [Label:b97e3] Label cannot be part of reaction. Tranforming to Unknown [Label:e0506] Label cannot be part of reaction. Tranforming to Unknown [Label:feab5] Label cannot be part of reaction. Tranforming to Unknown [Label:fec1c] Label cannot be part of reaction. Tranforming to Unknown [Label:ad4e7] Label cannot be part of reaction. Tranforming to Unknown [Label:c2b93] Label cannot be part of reaction. Tranforming to Unknown [Label:dd71a] Label cannot be part of reaction. Tranforming to Unknown [Label:e8200] Label cannot be part of reaction. Tranforming to Unknown [Label:a967a] Label cannot be part of reaction. Tranforming to Unknown [Label:f9467] Label cannot be part of reaction. Tranforming to Unknown [Label:fddb2] Label cannot be part of reaction. Tranforming to Unknown [Label:eea46] Label cannot be part of reaction. Tranforming to Unknown [Label:fa574] Label cannot be part of reaction. Tranforming to Unknown [Label:cf36c] Label cannot be part of reaction. Tranforming to Unknown [:e7dd3] Shape can not be part of reaction. Tranforming to Unknown [:c5102] Shape can not be part of reaction. Tranforming to Unknown [:f1edb] Rotation of objects is not supported. Rotation=5.807918387918681 [:c3c36] Rotation of objects is not supported. Rotation=5.807918387918681 [-:-] Miriam data (PUBMED: 17892308) for ida03b3e90 already exists. Ignoring... [-:-] Miriam data (PUBMED: 17892308) for ida03b3e90 already exists. Ignoring... [-:-] Miriam data (PUBMED: 17892308) for ida03b3e90 already exists. Ignoring... [-:-] Miriam data (PUBMED: 19700356) for c4929 already exists. Ignoring... [-:-] Miriam data (PUBMED: 21114891) for c4929 already exists. Ignoring... [-:-] Miriam data (PUBMED: 19700356) for id4cec09a9 already exists. Ignoring... [-:-] Miriam data (PUBMED: 19700356) for c2609 already exists. Ignoring... [Complex:ceb33] Empty element is invalid [Complex:cece0] Empty element is invalid [BiopaxReference:ad1] Publication type is not supported.